| 1 | |  Pachuca | 17 | 10 | 4 | 3 | 37 | 22 | 15 | 34 | B18:00 | 06/05/21 | R quarterfinal  FC Juarez 1 Pachuca 1 B20:00 | 09/05/21 | R quarterfinal Pachuca 0 FC Juarez 0 G17:00 | 12/05/21 | R semifinal Deportivo Toluca FC 0 Pachuca 2 M18:00 | 15/05/21 | R semifinal Pachuca 0 Deportivo Toluca FC 2 B19:00 | 20/05/21 | R final Pachuca 0 CF Monterrey 0 M01:30 | 24/05/21 | R final CF Monterrey 2 Pachuca 1 |
| 2 | |  CF Monterrey | 16 | 11 | 1 | 4 | 30 | 18 | 12 | 34 | G18:00 | 05/05/21 | R quarterfinal Club Leon 0 CF Monterrey 1 G17:00 | 08/05/21 | R quarterfinal CF Monterrey 3 Club Leon 2 G17:00 | 13/05/21 | R semifinal Atlas 1 CF Monterrey 2 G17:00 | 16/05/21 | R semifinal CF Monterrey 1 Atlas 0 B19:00 | 20/05/21 | R final Pachuca 0 CF Monterrey 0 G01:30 | 24/05/21 | R final CF Monterrey 2 Pachuca 1 |
| 3 | |  Club America | 16 | 10 | 2 | 4 | 28 | 12 | 16 | 32 | G17:00 | 10/04/21 | R 14 Tigres UANL 1 Club America 2 G19:00 | 17/04/21 | R 15 Club America 4 Cruz Azul 1 G17:00 | 25/04/21 | R 16 Deportivo Toluca FC 0 Club America 2 G19:30 | 01/05/21 | R 17 Pumas Unam 0 Club America 1 M17:00 | 05/05/21 | R quarterfinal Atlas 3 Club America 1 M19:00 | 08/05/21 | R quarterfinal Club America 0 Atlas 2 |
| 4 | |  Club Tijuana de Caliente | 17 | 10 | 1 | 6 | 26 | 16 | 10 | 31 | G01:45 | 12/04/21 | R 14 Club Tijuana de Caliente 1 Mazatlan FC 0 M17:00 | 17/04/21 | R 15 Chivas Guadalajara 2 Club Tijuana de Caliente 1 G01:45 | 24/04/21 | R 16 Club Tijuana de Caliente 3 Necaxa 1 G17:00 | 01/05/21 | R 17 Cruz Azul 0 Club Tijuana de Caliente 1 M17:00 | 06/05/21 | R quarterfinal Deportivo Toluca FC 1 Club Tijuana de Caliente 0 B07:00 | 10/05/21 | R quarterfinal Club Tijuana de Caliente 2 Deportivo Toluca FC 2 |
| 5 | |  Deportivo Toluca FC | 17 | 8 | 4 | 5 | 29 | 20 | 9 | 28 | M17:00 | 25/04/21 | R 16 Deportivo Toluca FC 0 Club America 2 B17:00 | 30/04/21 | R 17 FC Juarez 0 Deportivo Toluca FC 0 G17:00 | 06/05/21 | R quarterfinal Deportivo Toluca FC 1 Club Tijuana de Caliente 0 B07:00 | 10/05/21 | R quarterfinal Club Tijuana de Caliente 2 Deportivo Toluca FC 2 M17:00 | 12/05/21 | R semifinal Deportivo Toluca FC 0 Pachuca 2 G18:00 | 15/05/21 | R semifinal Pachuca 0 Deportivo Toluca FC 2 |
| 6 | |  Atlas | 17 | 8 | 4 | 5 | 25 | 19 | 6 | 28 | G17:00 | 24/04/21 | R 16 Atlas 3 Chivas Guadalajara 2 B17:00 | 30/04/21 | R 17 Necaxa 2 Atlas 2 G17:00 | 05/05/21 | R quarterfinal Atlas 3 Club America 1 G19:00 | 08/05/21 | R quarterfinal Club America 0 Atlas 2 M17:00 | 13/05/21 | R semifinal Atlas 1 CF Monterrey 2 M17:00 | 16/05/21 | R semifinal CF Monterrey 1 Atlas 0 |
| 7 | |  FC Juarez | 16 | 7 | 4 | 5 | 18 | 18 | 0 | 25 | M17:00 | 14/04/21 | R 5 FC Juarez 0 Tigres UANL 1 G17:00 | 19/04/21 | R 15 Club Leon 1 FC Juarez 2 G17:00 | 25/04/21 | R 16 Queretaro FC 0 FC Juarez 2 B17:00 | 30/04/21 | R 17 FC Juarez 0 Deportivo Toluca FC 0 B18:00 | 06/05/21 | R quarterfinal FC Juarez 1 Pachuca 1 B20:00 | 09/05/21 | R quarterfinal Pachuca 0 FC Juarez 0 |
| 8 | |  Club Leon | 16 | 8 | 1 | 7 | 26 | 29 | -3 | 25 | M17:00 | 10/04/21 | R 14 Atlas 2 Club Leon 1 M17:00 | 19/04/21 | R 15 Club Leon 1 FC Juarez 2 G18:00 | 23/04/21 | R 16 Mazatlan FC 1 Club Leon 3 G17:00 | 01/05/21 | R 17 Club Leon 3 Queretaro FC 0 M18:00 | 05/05/21 | R quarterfinal Club Leon 0 CF Monterrey 1 M17:00 | 08/05/21 | R quarterfinal CF Monterrey 3 Club Leon 2 |
| 9 | |  Puebla | 17 | 8 | 0 | 9 | 35 | 42 | -7 | 24 | G18:00 | 02/04/21 | R 13 Puebla 6 Mazatlan FC 2 M17:00 | 07/04/21 | R 4 Puebla 2 CF Monterrey 3 M20:00 | 12/04/21 | R 14 Pachuca 5 Puebla 2 M18:00 | 17/04/21 | R 15 Atletico San Luis 5 Puebla 3 G17:00 | 23/04/21 | R 16 Puebla 3 Pumas Unam 2 G19:00 | 02/05/21 | R 17 Club Santos Laguna 2 Puebla 3 |
| 10 | |  Tigres UANL | 17 | 6 | 5 | 6 | 27 | 20 | 7 | 23 | G17:00 | 04/04/21 | R 13 Queretaro FC 1 Tigres UANL 4 M17:00 | 10/04/21 | R 14 Tigres UANL 1 Club America 2 G17:00 | 14/04/21 | R 5 FC Juarez 0 Tigres UANL 1 G17:00 | 18/04/21 | R 15 Pumas Unam 2 Tigres UANL 4 B17:00 | 24/04/21 | R 16 Tigres UANL 2 CF Monterrey 2 B17:00 | 01/05/21 | R 17 Chivas Guadalajara 1 Tigres UANL 1 |
| 11 | |  Mazatlan FC | 17 | 6 | 4 | 7 | 26 | 30 | -4 | 22 | G19:00 | 19/03/21 | R 12 Mazatlan FC 1 Club America 0 M18:00 | 02/04/21 | R 13 Puebla 6 Mazatlan FC 2 M01:45 | 12/04/21 | R 14 Club Tijuana de Caliente 1 Mazatlan FC 0 B18:00 | 16/04/21 | R 15 Mazatlan FC 2 Atlas 2 M18:00 | 23/04/21 | R 16 Mazatlan FC 1 Club Leon 3 M17:00 | 01/05/21 | R 17 CF Monterrey 2 Mazatlan FC 0 |
| 12 | |  Atletico San Luis | 17 | 7 | 1 | 9 | 25 | 34 | -9 | 22 | M19:00 | 26/03/21 | R 4 Club Leon 4 Atletico San Luis 2 M18:00 | 03/04/21 | R 13 CF Monterrey 4 Atletico San Luis 1 B17:00 | 09/04/21 | R 14 FC Juarez 2 Atletico San Luis 2 G18:00 | 17/04/21 | R 15 Atletico San Luis 5 Puebla 3 G19:45 | 24/04/21 | R 16 Cruz Azul 0 Atletico San Luis 1 G18:00 | 29/04/21 | R 17 Atletico San Luis 2 Pachuca 0 |
| 13 | |  Chivas Guadalajara | 17 | 6 | 2 | 9 | 28 | 29 | -1 | 20 | G18:00 | 27/03/21 | R 1 Puebla 2 Chivas Guadalajara 4 G17:00 | 04/04/21 | R 13 Chivas Guadalajara 5 Club Santos Laguna 2 G17:00 | 10/04/21 | R 14 Cruz Azul 0 Chivas Guadalajara 1 G17:00 | 17/04/21 | R 15 Chivas Guadalajara 2 Club Tijuana de Caliente 1 M17:00 | 24/04/21 | R 16 Atlas 3 Chivas Guadalajara 2 B17:00 | 01/05/21 | R 17 Chivas Guadalajara 1 Tigres UANL 1 |
| 14 | |  Club Santos Laguna | 16 | 4 | 5 | 7 | 24 | 23 | 1 | 17 | G20:00 | 21/03/21 | R 12 Club Santos Laguna 3 Club Leon 0 M17:00 | 04/04/21 | R 13 Chivas Guadalajara 5 Club Santos Laguna 2 M17:00 | 11/04/21 | R 14 Queretaro FC 1 Club Santos Laguna 0 B19:00 | 18/04/21 | R 15 Club Santos Laguna 2 Deportivo Toluca FC 2 M20:00 | 26/04/21 | R 16 Pachuca 3 Club Santos Laguna 1 M19:00 | 02/05/21 | R 17 Club Santos Laguna 2 Puebla 3 |
| 15 | |  Necaxa | 17 | 4 | 4 | 9 | 19 | 26 | -7 | 16 | M18:00 | 19/03/21 | R 12 Necaxa 2 FC Juarez 4 M20:00 | 03/04/21 | R 13 Club America 1 Necaxa 0 G17:00 | 09/04/21 | R 14 Necaxa 1 Pumas Unam 0 G17:00 | 16/04/21 | R 15 Necaxa 4 Queretaro FC 1 M01:45 | 24/04/21 | R 16 Club Tijuana de Caliente 3 Necaxa 1 B17:00 | 30/04/21 | R 17 Necaxa 2 Atlas 2 |
| 16 | |  Pumas Unam | 17 | 4 | 4 | 9 | 24 | 34 | -10 | 16 | M19:00 | 20/03/21 | R 12 Atletico San Luis 2 Pumas Unam 1 B17:00 | 04/04/21 | R 13 Pumas Unam 4 Pachuca 4 M17:00 | 09/04/21 | R 14 Necaxa 1 Pumas Unam 0 M17:00 | 18/04/21 | R 15 Pumas Unam 2 Tigres UANL 4 M17:00 | 23/04/21 | R 16 Puebla 3 Pumas Unam 2 M19:30 | 01/05/21 | R 17 Pumas Unam 0 Club America 1 |
| 17 | |  Cruz Azul | 16 | 4 | 3 | 9 | 10 | 24 | -14 | 15 | G19:00 | 02/04/21 | R 13 FC Juarez 0 Cruz Azul 1 B20:00 | 07/04/21 | R 3 Pachuca 0 Cruz Azul 0 M17:00 | 10/04/21 | R 14 Cruz Azul 0 Chivas Guadalajara 1 M19:00 | 17/04/21 | R 15 Club America 4 Cruz Azul 1 M19:45 | 24/04/21 | R 16 Cruz Azul 0 Atletico San Luis 1 M17:00 | 01/05/21 | R 17 Cruz Azul 0 Club Tijuana de Caliente 1 |
| 18 | |  Queretaro FC | 17 | 4 | 1 | 12 | 13 | 34 | -21 | 13 | M00:45 | 21/03/21 | R 12 Club Tijuana de Caliente 1 Queretaro FC 0 M17:00 | 04/04/21 | R 13 Queretaro FC 1 Tigres UANL 4 G17:00 | 11/04/21 | R 14 Queretaro FC 1 Club Santos Laguna 0 M17:00 | 16/04/21 | R 15 Necaxa 4 Queretaro FC 1 M17:00 | 25/04/21 | R 16 Queretaro FC 0 FC Juarez 2 M17:00 | 01/05/21 | R 17 Club Leon 3 Queretaro FC 0 |
