| 1 | |  Fc Dynamo Kiev | 19 | 15 | 1 | 3 | 72 | 17 | 55 | 46 | G16:00 | 23/02/22 | R 19  Fc Dynamo Kiev 3 FC Ingulets 0 G12:00 | 12/12/21 | R 18 Fc Dynamo Kiev 5 FC Zorya Lugansk 1 G12:30 | 03/12/21 | R 17 NK Veres Rivne 0 Fc Dynamo Kiev 3 G13:30 | 28/11/21 | R 16 FC Minaj 0 Fc Dynamo Kiev 5 G14:00 | 18/11/21 | R 15 FC Chernomorets Odessa 0 Fc Dynamo Kiev 8 G14:00 | 06/11/21 | R 14 Fc Dynamo Kiev 5 FC Vorskla Poltava 1 |
| 2 | |  FC Rukh LVIV | 17 | 14 | 2 | 1 | 43 | 10 | 33 | 44 | G13:00 | 20/05/22 | R 1 FC Rukh LVIV 3 Kolos Kovalivka 0 G13:00 | 17/05/22 | R 11 FC Ingulets 1 FC Rukh LVIV 6 G12:00 | 15/12/21 | R 6 FC Rukh LVIV 2 FC Lviv 0 G14:00 | 10/12/21 | R 18 NK Veres Rivne 1 FC Rukh LVIV 2 G13:00 | 03/12/21 | R 17 FC Rukh LVIV 2 FC Vorskla Poltava 0 B13:00 | 26/11/21 | R 16 FC Rukh LVIV 1 FC Metalist 1925 Kharkiv 1 |
| 3 | |  FC Shakhtar Donetsk | 18 | 14 | 1 | 3 | 46 | 13 | 33 | 43 | G13:00 | 10/12/21 | R 18 FC Oleksandria 0 FC Shakhtar Donetsk 1 G12:00 | 02/12/21 | R 17 FC Shakhtar Donetsk 4 FC Lviv 0 M14:00 | 27/11/21 | R 16 FC Ingulets 1 FC Shakhtar Donetsk 0 B12:00 | 19/11/21 | R 15 FC Shakhtar Donetsk 0 FC Rukh LVIV 0 G12:00 | 07/11/21 | R 14 Kolos Kovalivka 1 FC Shakhtar Donetsk 3 G11:00 | 29/10/21 | R 13 FC Shakhtar Donetsk 4 FC Desna Chernihiv 0 |
| 4 | |  FC Metalist 1925 Kharkiv | 18 | 13 | 2 | 3 | 32 | 14 | 18 | 41 | G14:00 | 11/12/21 | R 18 FC Chernomorets Odessa 0 FC Metalist 1925 Kharkiv 1 G13:00 | 03/12/21 | R 17 FC Metalist 1925 Kharkiv 2 Kolos Kovalivka 1 B13:00 | 26/11/21 | R 16 FC Rukh LVIV 1 FC Metalist 1925 Kharkiv 1 G14:00 | 23/11/21 | R 15 NK Veres Rivne 0 FC Metalist 1925 Kharkiv 1 G15:00 | 04/11/21 | R 14 FC Oleksandria 0 FC Metalist 1925 Kharkiv 1 B14:00 | 30/10/21 | R 13 FC Metalist 1925 Kharkiv 1 FC Zorya Lugansk 1 |
| 5 | |  FC Zorya Lugansk | 18 | 10 | 4 | 4 | 57 | 23 | 34 | 34 | M12:00 | 12/12/21 | R 18 Fc Dynamo Kiev 5 FC Zorya Lugansk 1 G13:00 | 04/12/21 | R 17 FC Zorya Lugansk 7 FC Ingulets 1 G14:00 | 28/11/21 | R 16 FC Oleksandria 0 FC Zorya Lugansk 4 B13:00 | 19/11/21 | R 15 FC Lviv 0 FC Zorya Lugansk 0 G13:00 | 06/11/21 | R 14 FC Zorya Lugansk 4 NK Veres Rivne 0 B14:00 | 30/10/21 | R 13 FC Metalist 1925 Kharkiv 1 FC Zorya Lugansk 1 |
| 6 | |  FC Vorskla Poltava | 18 | 10 | 2 | 6 | 32 | 23 | 9 | 32 | G13:00 | 10/12/21 | R 18 FC Lviv 0 FC Vorskla Poltava 2 M13:00 | 03/12/21 | R 17 FC Rukh LVIV 2 FC Vorskla Poltava 0 M14:00 | 26/11/21 | R 16 SC Dnipro-1 2 FC Vorskla Poltava 1 G14:00 | 20/11/21 | R 15 FC Vorskla Poltava 3 FC Mariupol 2 M14:00 | 06/11/21 | R 14 Fc Dynamo Kiev 5 FC Vorskla Poltava 1 B13:00 | 31/10/21 | R 13 FC Vorskla Poltava 0 FC Chernomorets Odessa 0 |
| 7 | |  SC Dnipro-1 | 17 | 9 | 2 | 6 | 33 | 27 | 6 | 29 | G13:00 | 09/12/21 | R 18 FC Mariupol 1 SC Dnipro-1 4 G13:00 | 05/12/21 | R 17 SC Dnipro-1 3 FC Chernomorets Odessa 0 G14:00 | 26/11/21 | R 16 SC Dnipro-1 2 FC Vorskla Poltava 1 G14:00 | 19/11/21 | R 15 SC Dnipro-1 3 FC Oleksandria 0 B14:00 | 06/11/21 | R 14 FC Ingulets 1 SC Dnipro-1 1 B12:00 | 30/10/21 | R 13 SC Dnipro-1 2 FC Minaj 2 |
| 8 | |  FC Oleksandria | 18 | 8 | 3 | 7 | 21 | 29 | -8 | 27 | M13:00 | 10/12/21 | R 18 FC Oleksandria 0 FC Shakhtar Donetsk 1 G13:00 | 04/12/21 | R 17 FC Oleksandria 3 FC Minaj 0 M14:00 | 28/11/21 | R 16 FC Oleksandria 0 FC Zorya Lugansk 4 M14:00 | 19/11/21 | R 15 SC Dnipro-1 3 FC Oleksandria 0 M15:00 | 04/11/21 | R 14 FC Oleksandria 0 FC Metalist 1925 Kharkiv 1 M11:30 | 30/10/21 | R 13 FC Rukh LVIV 5 FC Oleksandria 1 |
| 9 | |  Kolos Kovalivka | 19 | 7 | 1 | 11 | 24 | 32 | -8 | 22 | M13:00 | 20/05/22 | R 1 FC Rukh LVIV 3 Kolos Kovalivka 0 M14:00 | 11/12/21 | R 18 Kolos Kovalivka 0 FC Minaj 1 M13:00 | 03/12/21 | R 17 FC Metalist 1925 Kharkiv 2 Kolos Kovalivka 1 G13:00 | 27/11/21 | R 16 Kolos Kovalivka 2 NK Veres Rivne 0 G15:00 | 20/11/21 | R 15 FC Desna Chernihiv 0 Kolos Kovalivka 7 M12:00 | 07/11/21 | R 14 Kolos Kovalivka 1 FC Shakhtar Donetsk 3 |
| 10 | |  FC Chernomorets Odessa | 18 | 6 | 4 | 8 | 18 | 31 | -13 | 22 | M14:00 | 11/12/21 | R 18 FC Chernomorets Odessa 0 FC Metalist 1925 Kharkiv 1 M13:00 | 05/12/21 | R 17 SC Dnipro-1 3 FC Chernomorets Odessa 0 G13:00 | 26/11/21 | R 16 FC Chernomorets Odessa 1 FC Desna Chernihiv 0 M14:00 | 18/11/21 | R 15 FC Chernomorets Odessa 0 Fc Dynamo Kiev 8 M13:00 | 05/11/21 | R 14 FC Chernomorets Odessa 0 FC Rukh LVIV 3 B13:00 | 31/10/21 | R 13 FC Vorskla Poltava 0 FC Chernomorets Odessa 0 |
| 11 | |  FC Mariupol | 18 | 7 | 0 | 11 | 25 | 31 | -6 | 21 | M13:00 | 09/12/21 | R 18 FC Mariupol 1 SC Dnipro-1 4 M13:00 | 04/12/21 | R 17 FC Desna Chernihiv 1 FC Mariupol 0 M13:00 | 25/11/21 | R 16 FC Mariupol 0 FC Lviv 1 M14:00 | 20/11/21 | R 15 FC Vorskla Poltava 3 FC Mariupol 2 G13:00 | 05/11/21 | R 14 FC Minaj 0 FC Mariupol 1 G12:00 | 28/10/21 | R 13 FC Mariupol 1 Fc Dynamo Kiev 0 |
| 12 | |  FC Lviv | 18 | 5 | 2 | 11 | 12 | 31 | -19 | 17 | M12:00 | 15/12/21 | R 6 FC Rukh LVIV 2 FC Lviv 0 M13:00 | 10/12/21 | R 18 FC Lviv 0 FC Vorskla Poltava 2 M12:00 | 02/12/21 | R 17 FC Shakhtar Donetsk 4 FC Lviv 0 G13:00 | 25/11/21 | R 16 FC Mariupol 0 FC Lviv 1 B13:00 | 19/11/21 | R 15 FC Lviv 0 FC Zorya Lugansk 0 M13:00 | 06/11/21 | R 14 FC Lviv 0 FC Desna Chernihiv 1 |
| 13 | |  FC Ingulets | 18 | 4 | 2 | 12 | 19 | 36 | -17 | 14 | M13:00 | 17/05/22 | R 11 FC Ingulets 1 FC Rukh LVIV 6 M16:00 | 23/02/22 | R 19 Fc Dynamo Kiev 3 FC Ingulets 0 G14:00 | 09/12/21 | R 18 FC Ingulets 5 FC Desna Chernihiv 2 M13:00 | 04/12/21 | R 17 FC Zorya Lugansk 7 FC Ingulets 1 G14:00 | 27/11/21 | R 16 FC Ingulets 1 FC Shakhtar Donetsk 0 M13:00 | 20/11/21 | R 15 FC Minaj 4 FC Ingulets 0 |
| 14 | |  FC Minaj | 18 | 3 | 3 | 12 | 17 | 39 | -22 | 12 | G14:00 | 11/12/21 | R 18 Kolos Kovalivka 0 FC Minaj 1 M13:00 | 04/12/21 | R 17 FC Oleksandria 3 FC Minaj 0 M13:30 | 28/11/21 | R 16 FC Minaj 0 Fc Dynamo Kiev 5 G13:00 | 20/11/21 | R 15 FC Minaj 4 FC Ingulets 0 M13:00 | 05/11/21 | R 14 FC Minaj 0 FC Mariupol 1 B12:00 | 30/10/21 | R 13 SC Dnipro-1 2 FC Minaj 2 |
| 15 | |  NK Veres Rivne | 18 | 2 | 1 | 15 | 9 | 45 | -36 | 7 | M14:00 | 10/12/21 | R 18 NK Veres Rivne 1 FC Rukh LVIV 2 M12:30 | 03/12/21 | R 17 NK Veres Rivne 0 Fc Dynamo Kiev 3 M13:00 | 27/11/21 | R 16 Kolos Kovalivka 2 NK Veres Rivne 0 M14:00 | 23/11/21 | R 15 NK Veres Rivne 0 FC Metalist 1925 Kharkiv 1 M13:00 | 06/11/21 | R 14 FC Zorya Lugansk 4 NK Veres Rivne 0 M13:00 | 29/10/21 | R 13 FC Ingulets 3 NK Veres Rivne 0 |
| 16 | |  FC Desna Chernihiv | 18 | 2 | 0 | 16 | 9 | 68 | -59 | 6 | M14:00 | 09/12/21 | R 18 FC Ingulets 5 FC Desna Chernihiv 2 G13:00 | 04/12/21 | R 17 FC Desna Chernihiv 1 FC Mariupol 0 M13:00 | 26/11/21 | R 16 FC Chernomorets Odessa 1 FC Desna Chernihiv 0 M15:00 | 20/11/21 | R 15 FC Desna Chernihiv 0 Kolos Kovalivka 7 G13:00 | 06/11/21 | R 14 FC Lviv 0 FC Desna Chernihiv 1 M11:00 | 29/10/21 | R 13 FC Shakhtar Donetsk 4 FC Desna Chernihiv 0 |
