| 1 | |  FC Pakhtakor Tashkent | 26 | 19 | 3 | 4 | 51 | 18 | 33 | 60 | M14:00 | 01/10/21 | R 21  FK Kokand 1912 4 FC Pakhtakor Tashkent 2 G14:15 | 16/10/21 | R 22 FC Pakhtakor Tashkent 4 Qizilqum Zarafshon 2 M14:00 | 24/10/21 | R 23 PFC Sogdiana 1 FC Pakhtakor Tashkent 0 G15:00 | 06/11/21 | R 24 FC Pakhtakor Tashkent 5 FK Termez Surkhon 0 G14:15 | 20/11/21 | R 25 Lokomotif Tashkent 0 FC Pakhtakor Tashkent 3 M13:00 | 27/11/21 | R 26 FC Bunyodkor 3 FC Pakhtakor Tashkent 2 |
| 2 | |  PFC Sogdiana | 26 | 12 | 11 | 3 | 28 | 15 | 13 | 47 | B13:45 | 02/10/21 | R 21 FC Andijon 0 PFC Sogdiana 0 B16:30 | 16/10/21 | R 22 PFC Sogdiana 1 FK Kokand 1912 1 G14:00 | 24/10/21 | R 23 PFC Sogdiana 1 FC Pakhtakor Tashkent 0 M14:00 | 05/11/21 | R 24 Lokomotif Tashkent 1 PFC Sogdiana 0 B12:00 | 20/11/21 | R 1 PFC Sogdiana 1 FC Nasaf 1 G13:00 | 27/11/21 | R 26 FK Agmk 0 PFC Sogdiana 1 |
| 3 | |  FK Agmk | 26 | 13 | 8 | 5 | 34 | 25 | 9 | 47 | B16:00 | 02/10/21 | R 21 FC Bunyodkor 1 FK Agmk 1 G15:00 | 15/10/21 | R 22 FK Agmk 3 PFK Mashal Mubarek 2 G16:15 | 21/10/21 | R 23 PFK Metallurg Bekabad 0 FK Agmk 1 G14:00 | 04/11/21 | R 24 FK Agmk 3 FC Andijon 2 B12:00 | 20/11/21 | R 25 FK Kokand 1912 2 FK Agmk 2 M13:00 | 27/11/21 | R 26 FK Agmk 0 PFC Sogdiana 1 |
| 4 | |  FC Nasaf | 26 | 13 | 6 | 7 | 42 | 24 | 18 | 45 | G16:30 | 15/10/21 | R 22 FC Nasaf 1 PFK Metallurg Bekabad 0 B13:15 | 25/10/21 | R 23 FC Andijon 1 FC Nasaf 1 B13:00 | 11/11/21 | R 19 FK Termez Surkhon 2 FC Nasaf 2 G12:00 | 15/11/21 | R 24 FC Nasaf 3 FK Kokand 1912 1 B12:00 | 20/11/21 | R 1 PFC Sogdiana 1 FC Nasaf 1 M13:00 | 27/11/21 | R 26 FC Nasaf 1 Lokomotif Tashkent 3 |
| 5 | |  FC Bunyodkor | 26 | 13 | 6 | 7 | 43 | 30 | 13 | 45 | B16:00 | 02/10/21 | R 21 FC Bunyodkor 1 FK Agmk 1 M15:00 | 17/10/21 | R 22 PFK Navbahor Namangan 2 FC Bunyodkor 1 G16:15 | 22/10/21 | R 23 FC Bunyodkor 3 FK Turon 1 G16:15 | 04/11/21 | R 24 FC Bunyodkor 1 Qizilqum Zarafshon 0 G14:15 | 20/11/21 | R 25 FC Bunyodkor 3 FK Termez Surkhon 1 G13:00 | 27/11/21 | R 26 FC Bunyodkor 3 FC Pakhtakor Tashkent 2 |
| 6 | |  PFK Navbahor Namangan | 26 | 10 | 9 | 7 | 23 | 19 | 4 | 39 | M14:00 | 03/10/21 | R 21 FK Termez Surkhon 1 PFK Navbahor Namangan 0 G15:00 | 17/10/21 | R 22 PFK Navbahor Namangan 2 FC Bunyodkor 1 B13:45 | 23/10/21 | R 23 PFK Mashal Mubarek 0 PFK Navbahor Namangan 0 G16:15 | 05/11/21 | R 24 PFK Navbahor Namangan 1 PFK Metallurg Bekabad 0 G12:00 | 21/11/21 | R 25 FC Andijon 1 PFK Navbahor Namangan 2 M13:00 | 27/11/21 | R 26 PFK Navbahor Namangan 2 FK Kokand 1912 3 |
| 7 | |  Lokomotif Tashkent | 26 | 11 | 6 | 9 | 37 | 32 | 5 | 39 | G16:15 | 01/10/21 | R 21 PFK Metallurg Bekabad 1 Lokomotif Tashkent 2 B15:00 | 17/10/21 | R 22 Lokomotif Tashkent 2 FC Andijon 2 M13:15 | 23/10/21 | R 23 FK Kokand 1912 2 Lokomotif Tashkent 1 G14:00 | 05/11/21 | R 24 Lokomotif Tashkent 1 PFC Sogdiana 0 M14:15 | 20/11/21 | R 25 Lokomotif Tashkent 0 FC Pakhtakor Tashkent 3 G13:00 | 27/11/21 | R 26 FC Nasaf 1 Lokomotif Tashkent 3 |
| 8 | |  FK Kokand 1912 | 26 | 9 | 9 | 8 | 37 | 36 | 1 | 36 | G14:00 | 01/10/21 | R 21 FK Kokand 1912 4 FC Pakhtakor Tashkent 2 B16:30 | 16/10/21 | R 22 PFC Sogdiana 1 FK Kokand 1912 1 G13:15 | 23/10/21 | R 23 FK Kokand 1912 2 Lokomotif Tashkent 1 M12:00 | 15/11/21 | R 24 FC Nasaf 3 FK Kokand 1912 1 B12:00 | 20/11/21 | R 25 FK Kokand 1912 2 FK Agmk 2 G13:00 | 27/11/21 | R 26 PFK Navbahor Namangan 2 FK Kokand 1912 3 |
| 9 | |  Qizilqum Zarafshon | 26 | 7 | 10 | 9 | 26 | 29 | -3 | 31 | G16:15 | 03/10/21 | R 21 Qizilqum Zarafshon 2 FK Turon 1 M14:15 | 16/10/21 | R 22 FC Pakhtakor Tashkent 4 Qizilqum Zarafshon 2 M13:30 | 22/10/21 | R 23 FK Termez Surkhon 1 Qizilqum Zarafshon 0 M16:15 | 04/11/21 | R 24 FC Bunyodkor 1 Qizilqum Zarafshon 0 M12:00 | 21/11/21 | R 25 PFK Mashal Mubarek 2 Qizilqum Zarafshon 1 M13:00 | 27/11/21 | R 26 Qizilqum Zarafshon 1 PFK Metallurg Bekabad 3 |
| 10 | |  FK Termez Surkhon | 26 | 7 | 4 | 15 | 17 | 43 | -26 | 25 | B15:00 | 16/10/21 | R 22 FK Turon 1 FK Termez Surkhon 1 G13:30 | 22/10/21 | R 23 FK Termez Surkhon 1 Qizilqum Zarafshon 0 M15:00 | 06/11/21 | R 24 FC Pakhtakor Tashkent 5 FK Termez Surkhon 0 B13:00 | 11/11/21 | R 19 FK Termez Surkhon 2 FC Nasaf 2 M14:15 | 20/11/21 | R 25 FC Bunyodkor 3 FK Termez Surkhon 1 G13:00 | 27/11/21 | R 26 FK Termez Surkhon 1 PFK Mashal Mubarek 0 |
| 11 | |  PFK Metallurg Bekabad | 26 | 8 | 1 | 17 | 22 | 35 | -13 | 25 | M16:15 | 01/10/21 | R 21 PFK Metallurg Bekabad 1 Lokomotif Tashkent 2 M16:30 | 15/10/21 | R 22 FC Nasaf 1 PFK Metallurg Bekabad 0 M16:15 | 21/10/21 | R 23 PFK Metallurg Bekabad 0 FK Agmk 1 M16:15 | 05/11/21 | R 24 PFK Navbahor Namangan 1 PFK Metallurg Bekabad 0 G14:15 | 21/11/21 | R 25 PFK Metallurg Bekabad 1 FK Turon 0 G13:00 | 27/11/21 | R 26 Qizilqum Zarafshon 1 PFK Metallurg Bekabad 3 |
| 12 | |  PFK Mashal Mubarek | 26 | 5 | 8 | 13 | 21 | 35 | -14 | 23 | M15:00 | 15/10/21 | R 22 FK Agmk 3 PFK Mashal Mubarek 2 B13:45 | 23/10/21 | R 23 PFK Mashal Mubarek 0 PFK Navbahor Namangan 0 B12:45 | 06/11/21 | R 24 PFK Mashal Mubarek 0 FK Turon 0 G12:00 | 21/11/21 | R 25 PFK Mashal Mubarek 2 Qizilqum Zarafshon 1 M13:00 | 27/11/21 | R 26 FK Termez Surkhon 1 PFK Mashal Mubarek 0 M14:00 | 02/12/21 | R final FC Olimpik 3 PFK Mashal Mubarek 1 |
| 13 | |  FC Andijon | 26 | 4 | 7 | 15 | 22 | 41 | -19 | 19 | B13:45 | 02/10/21 | R 21 FC Andijon 0 PFC Sogdiana 0 B15:00 | 17/10/21 | R 22 Lokomotif Tashkent 2 FC Andijon 2 B13:15 | 25/10/21 | R 23 FC Andijon 1 FC Nasaf 1 M14:00 | 04/11/21 | R 24 FK Agmk 3 FC Andijon 2 M12:00 | 21/11/21 | R 25 FC Andijon 1 PFK Navbahor Namangan 2 M13:00 | 27/11/21 | R 26 FK Turon 1 FC Andijon 0 |
| 14 | |  FK Turon | 26 | 3 | 8 | 15 | 16 | 37 | -21 | 17 | M16:15 | 03/10/21 | R 21 Qizilqum Zarafshon 2 FK Turon 1 B15:00 | 16/10/21 | R 22 FK Turon 1 FK Termez Surkhon 1 M16:15 | 22/10/21 | R 23 FC Bunyodkor 3 FK Turon 1 B12:45 | 06/11/21 | R 24 PFK Mashal Mubarek 0 FK Turon 0 M14:15 | 21/11/21 | R 25 PFK Metallurg Bekabad 1 FK Turon 0 G13:00 | 27/11/21 | R 26 FK Turon 1 FC Andijon 0 |
