| 1 | |  Libertad Asuncion | 18 | 12 | 2 | 4 | 36 | 15 | 21 | 38 | B03:00 | 26/04/21 | R 13  Libertad Asuncion 1 Nacional Asuncion 1 G02:00 | 04/05/21 | R 14 Club River Plate Asuncion 1 Libertad Asuncion 3 G00:45 | 10/05/21 | R 15 Libertad Asuncion 3 12 De Octubre De Itaugua 1 G03:00 | 17/05/21 | R 16 Club Guarani 1 Libertad Asuncion 6 M00:45 | 23/05/21 | R 17 Libertad Asuncion 1 Sol De America 2 G00:45 | 30/05/21 | R 18 Sportiva Luqueno 1 Libertad Asuncion 3 |
| 2 | |  Club Olimpia | 18 | 10 | 3 | 5 | 34 | 23 | 11 | 33 | G03:00 | 25/04/21 | R 13 Club Olimpia 2 Club Guarani 1 M03:00 | 02/05/21 | R 14 Cerro Porteno 2 Club Olimpia 0 B00:45 | 10/05/21 | R 15 Club Olimpia 3 Sol De America 3 M01:00 | 18/05/21 | R 16 Nacional Asuncion 2 Club Olimpia 1 G00:45 | 24/05/21 | R 17 Club Olimpia 4 Sportiva Luqueno 1 G00:45 | 31/05/21 | R 18 Club River Plate Asuncion 1 Club Olimpia 2 |
| 3 | |  Nacional Asuncion | 18 | 8 | 6 | 4 | 26 | 19 | 7 | 30 | B03:00 | 26/04/21 | R 13 Libertad Asuncion 1 Nacional Asuncion 1 M01:00 | 01/05/21 | R 14 Nacional Asuncion 1 Guairena FC 3 B03:00 | 09/05/21 | R 15 Cerro Porteno 2 Nacional Asuncion 2 G01:00 | 18/05/21 | R 16 Nacional Asuncion 2 Club Olimpia 1 M03:00 | 24/05/21 | R 17 Nacional Asuncion 0 Club River Plate Asuncion 1 B03:00 | 31/05/21 | R 18 12 De Octubre De Itaugua 2 Nacional Asuncion 2 |
| 4 | |  Cerro Porteno | 18 | 8 | 4 | 6 | 24 | 22 | 2 | 28 | G00:45 | 26/04/21 | R 13 Guairena FC 0 Cerro Porteno 1 G03:00 | 02/05/21 | R 14 Cerro Porteno 2 Club Olimpia 0 B03:00 | 09/05/21 | R 15 Cerro Porteno 2 Nacional Asuncion 2 B00:45 | 17/05/21 | R 16 Club River Plate Asuncion 1 Cerro Porteno 1 M15:30 | 23/05/21 | R 17 Cerro Porteno 0 12 De Octubre De Itaugua 1 M03:00 | 29/05/21 | R 18 Club Guarani 2 Cerro Porteno 0 |
| 5 | |  Guairena FC | 18 | 6 | 8 | 4 | 20 | 14 | 6 | 26 | M00:45 | 26/04/21 | R 13 Guairena FC 0 Cerro Porteno 1 G01:00 | 01/05/21 | R 14 Nacional Asuncion 1 Guairena FC 3 B03:00 | 10/05/21 | R 15 Guairena FC 0 Club River Plate Asuncion 0 B03:00 | 16/05/21 | R 16 12 De Octubre De Itaugua 1 Guairena FC 1 B02:00 | 22/05/21 | R 17 Guairena FC 0 Club Guarani 0 B00:45 | 29/05/21 | R 18 Sol De America 0 Guairena FC 0 |
| 6 | |  Club Guarani | 18 | 7 | 4 | 7 | 24 | 27 | -3 | 25 | M03:00 | 25/04/21 | R 13 Club Olimpia 2 Club Guarani 1 G00:45 | 03/05/21 | R 14 Club Guarani 2 Sol De America 0 G00:45 | 09/05/21 | R 15 Sportiva Luqueno 1 Club Guarani 2 M03:00 | 17/05/21 | R 16 Club Guarani 1 Libertad Asuncion 6 B02:00 | 22/05/21 | R 17 Guairena FC 0 Club Guarani 0 G03:00 | 29/05/21 | R 18 Club Guarani 2 Cerro Porteno 0 |
| 7 | |  12 De Octubre De Itaugua | 18 | 5 | 7 | 6 | 20 | 25 | -5 | 22 | G02:00 | 24/04/21 | R 13 Sol De America 0 12 De Octubre De Itaugua 3 G03:15 | 01/05/21 | R 14 12 De Octubre De Itaugua 1 Sportiva Luqueno 0 M00:45 | 10/05/21 | R 15 Libertad Asuncion 3 12 De Octubre De Itaugua 1 B03:00 | 16/05/21 | R 16 12 De Octubre De Itaugua 1 Guairena FC 1 G15:30 | 23/05/21 | R 17 Cerro Porteno 0 12 De Octubre De Itaugua 1 B03:00 | 31/05/21 | R 18 12 De Octubre De Itaugua 2 Nacional Asuncion 2 |
| 8 | |  Sportiva Luqueno | 18 | 5 | 3 | 10 | 19 | 29 | -10 | 18 | B01:15 | 27/04/21 | R 13 Sportiva Luqueno 2 Club River Plate Asuncion 2 M03:15 | 01/05/21 | R 14 12 De Octubre De Itaugua 1 Sportiva Luqueno 0 M00:45 | 09/05/21 | R 15 Sportiva Luqueno 1 Club Guarani 2 G00:45 | 16/05/21 | R 16 Sol De America 0 Sportiva Luqueno 2 M00:45 | 24/05/21 | R 17 Club Olimpia 4 Sportiva Luqueno 1 M00:45 | 30/05/21 | R 18 Sportiva Luqueno 1 Libertad Asuncion 3 |
| 9 | |  Sol De America | 18 | 3 | 5 | 10 | 18 | 28 | -10 | 14 | M02:00 | 24/04/21 | R 13 Sol De America 0 12 De Octubre De Itaugua 3 M00:45 | 03/05/21 | R 14 Club Guarani 2 Sol De America 0 B00:45 | 10/05/21 | R 15 Club Olimpia 3 Sol De America 3 M00:45 | 16/05/21 | R 16 Sol De America 0 Sportiva Luqueno 2 G00:45 | 23/05/21 | R 17 Libertad Asuncion 1 Sol De America 2 B00:45 | 29/05/21 | R 18 Sol De America 0 Guairena FC 0 |
| 10 | |  Club River Plate Asuncion | 18 | 2 | 6 | 10 | 13 | 32 | -19 | 12 | B01:15 | 27/04/21 | R 13 Sportiva Luqueno 2 Club River Plate Asuncion 2 M02:00 | 04/05/21 | R 14 Club River Plate Asuncion 1 Libertad Asuncion 3 B03:00 | 10/05/21 | R 15 Guairena FC 0 Club River Plate Asuncion 0 B00:45 | 17/05/21 | R 16 Club River Plate Asuncion 1 Cerro Porteno 1 G03:00 | 24/05/21 | R 17 Nacional Asuncion 0 Club River Plate Asuncion 1 M00:45 | 31/05/21 | R 18 Club River Plate Asuncion 1 Club Olimpia 2 |
