| 1 | |  FC Barcelona | 30 | 30 | 0 | 0 | 159 | 11 | 148 | 90 | G14:00 | 26/03/22 | R 25  Madrid CCF 1 FC Barcelona 2 G13:00 | 02/04/22 | R 26 FC Barcelona 6 Villarreal CF 1 G13:00 | 16/04/22 | R 27 Valencia CF 0 FC Barcelona 2 G18:00 | 05/05/22 | R 28 FC Barcelona 5 Sevilla FC 1 G17:00 | 08/05/22 | R 29 Rayo Vallecano 1 FC Barcelona 6 G13:00 | 15/05/22 | R 30 FC Barcelona 2 Atletico Madrid 1 |
| 2 | |  Real Sociedad San Sebastian | 30 | 21 | 3 | 6 | 67 | 38 | 29 | 66 | G13:00 | 27/03/22 | R 25 Sporting Club de Huelva 1 Real Sociedad San Sebastian 2 M13:30 | 02/04/22 | R 26 Real Sociedad San Sebastian 0 Madrid CCF 1 G13:00 | 16/04/22 | R 27 Sevilla FC 1 Real Sociedad San Sebastian 2 G13:00 | 01/05/22 | R 28 Real Sociedad San Sebastian 4 Rayo Vallecano 0 B13:00 | 08/05/22 | R 29 UDG Tenerife 1 Real Sociedad San Sebastian 1 G13:00 | 15/05/22 | R 30 Real Sociedad San Sebastian 6 Deportivo Alaves 1 |
| 3 | |  Real Madrid | 30 | 19 | 3 | 8 | 41 | 31 | 10 | 60 | M13:00 | 03/04/22 | R 26 Sporting Club de Huelva 3 Real Madrid 1 G12:00 | 17/04/22 | R 27 Deportivo Alaves 0 Real Madrid 1 G18:00 | 20/04/22 | R 18 Rayo Vallecano 0 Real Madrid 1 G12:00 | 01/05/22 | R 28 Real Madrid 1 Madrid CCF 0 B13:00 | 08/05/22 | R 29 Valencia CF 0 Real Madrid 0 G13:00 | 15/05/22 | R 30 Real Madrid 1 Villarreal CF 0 |
| 4 | |  Atletico Madrid | 30 | 17 | 8 | 5 | 71 | 28 | 43 | 59 | G15:00 | 26/03/22 | R 25 Atletico Madrid 3 Valencia CF 0 B18:00 | 02/04/22 | R 26 Real Betis Seville 1 Atletico Madrid 1 G13:00 | 17/04/22 | R 27 Atletico Madrid 3 Athletic Bilbao 0 G12:00 | 01/05/22 | R 28 Levante UD 0 Atletico Madrid 5 G13:00 | 08/05/22 | R 29 Atletico Madrid 3 SD Eibar 1 M13:00 | 15/05/22 | R 30 FC Barcelona 2 Atletico Madrid 1 |
| 5 | |  UDG Tenerife | 30 | 16 | 6 | 8 | 42 | 44 | -2 | 54 | B14:00 | 27/03/22 | R 25 UDG Tenerife 0 Real Betis Seville 0 G13:00 | 03/04/22 | R 26 Rayo Vallecano 1 UDG Tenerife 2 G14:00 | 16/04/22 | R 27 UDG Tenerife 3 SD Eibar 2 M13:00 | 30/04/22 | R 28 Athletic Bilbao 2 UDG Tenerife 1 B13:00 | 08/05/22 | R 29 UDG Tenerife 1 Real Sociedad San Sebastian 1 M21:30 | 14/05/22 | R 30 Levante UD 4 UDG Tenerife 1 |
| 6 | |  Levante UD | 30 | 15 | 5 | 10 | 52 | 39 | 13 | 50 | G17:00 | 30/03/22 | R 24 Levante UD 3 Deportivo Alaves 0 G12:00 | 03/04/22 | R 26 Levante UD 3 Sevilla FC 0 G12:00 | 17/04/22 | R 27 Rayo Vallecano 3 Levante UD 4 M12:00 | 01/05/22 | R 28 Levante UD 0 Atletico Madrid 5 G17:00 | 08/05/22 | R 29 Madrid CCF 1 Levante UD 3 G21:30 | 14/05/22 | R 30 Levante UD 4 UDG Tenerife 1 |
| 7 | |  Athletic Bilbao | 30 | 14 | 5 | 11 | 45 | 47 | -2 | 47 | B19:00 | 26/03/22 | R 25 Villarreal CF 1 Athletic Bilbao 1 B13:00 | 02/04/22 | R 26 Athletic Bilbao 2 Valencia CF 2 M13:00 | 17/04/22 | R 27 Atletico Madrid 3 Athletic Bilbao 0 G13:00 | 30/04/22 | R 28 Athletic Bilbao 2 UDG Tenerife 1 G13:00 | 07/05/22 | R 29 Deportivo Alaves 1 Athletic Bilbao 3 M13:00 | 15/05/22 | R 30 Athletic Bilbao 1 Sevilla FC 4 |
| 8 | |  Sevilla FC | 30 | 10 | 8 | 12 | 37 | 52 | -15 | 38 | G14:00 | 26/03/22 | R 25 Sevilla FC 4 SD Eibar 1 M12:00 | 03/04/22 | R 26 Levante UD 3 Sevilla FC 0 M13:00 | 16/04/22 | R 27 Sevilla FC 1 Real Sociedad San Sebastian 2 M18:00 | 05/05/22 | R 28 FC Barcelona 5 Sevilla FC 1 G13:00 | 08/05/22 | R 29 Sevilla FC 3 Sporting Club de Huelva 1 G13:00 | 15/05/22 | R 30 Athletic Bilbao 1 Sevilla FC 4 |
| 9 | |  Real Betis Seville | 30 | 7 | 10 | 13 | 31 | 52 | -21 | 31 | B14:00 | 27/03/22 | R 25 UDG Tenerife 0 Real Betis Seville 0 B18:00 | 02/04/22 | R 26 Real Betis Seville 1 Atletico Madrid 1 B13:00 | 17/04/22 | R 27 Madrid CCF 2 Real Betis Seville 2 B12:30 | 30/04/22 | R 28 Real Betis Seville 0 Valencia CF 0 M13:00 | 08/05/22 | R 29 Villarreal CF 2 Real Betis Seville 0 M12:30 | 14/05/22 | R 30 Real Betis Seville 1 Rayo Vallecano 3 |
| 10 | |  Sporting Club de Huelva | 30 | 6 | 13 | 11 | 28 | 44 | -16 | 31 | M13:00 | 27/03/22 | R 25 Sporting Club de Huelva 1 Real Sociedad San Sebastian 2 G13:00 | 03/04/22 | R 26 Sporting Club de Huelva 3 Real Madrid 1 B13:00 | 17/04/22 | R 27 Villarreal CF 1 Sporting Club de Huelva 1 G13:00 | 01/05/22 | R 28 Sporting Club de Huelva 2 Deportivo Alaves 1 M13:00 | 08/05/22 | R 29 Sevilla FC 3 Sporting Club de Huelva 1 G12:30 | 15/05/22 | R 30 Sporting Club de Huelva 2 Madrid CCF 0 |
| 11 | |  Deportivo Alaves | 30 | 8 | 6 | 16 | 30 | 63 | -33 | 30 | M17:00 | 30/03/22 | R 24 Levante UD 3 Deportivo Alaves 0 M12:30 | 03/04/22 | R 26 SD Eibar 2 Deportivo Alaves 0 M12:00 | 17/04/22 | R 27 Deportivo Alaves 0 Real Madrid 1 M13:00 | 01/05/22 | R 28 Sporting Club de Huelva 2 Deportivo Alaves 1 M13:00 | 07/05/22 | R 29 Deportivo Alaves 1 Athletic Bilbao 3 M13:00 | 15/05/22 | R 30 Real Sociedad San Sebastian 6 Deportivo Alaves 1 |
| 12 | |  Villarreal CF | 30 | 8 | 5 | 17 | 29 | 63 | -34 | 29 | M19:00 | 30/03/22 | R 24 Valencia CF 2 Villarreal CF 1 M13:00 | 02/04/22 | R 26 FC Barcelona 6 Villarreal CF 1 B13:00 | 17/04/22 | R 27 Villarreal CF 1 Sporting Club de Huelva 1 B12:30 | 01/05/22 | R 28 SD Eibar 1 Villarreal CF 1 G13:00 | 08/05/22 | R 29 Villarreal CF 2 Real Betis Seville 0 M13:00 | 15/05/22 | R 30 Real Madrid 1 Villarreal CF 0 |
| 13 | |  Madrid CCF | 30 | 8 | 3 | 19 | 42 | 64 | -22 | 27 | M14:00 | 26/03/22 | R 25 Madrid CCF 1 FC Barcelona 2 G13:30 | 02/04/22 | R 26 Real Sociedad San Sebastian 0 Madrid CCF 1 B13:00 | 17/04/22 | R 27 Madrid CCF 2 Real Betis Seville 2 M12:00 | 01/05/22 | R 28 Real Madrid 1 Madrid CCF 0 M17:00 | 08/05/22 | R 29 Madrid CCF 1 Levante UD 3 M12:30 | 15/05/22 | R 30 Sporting Club de Huelva 2 Madrid CCF 0 |
| 14 | |  Valencia CF | 30 | 7 | 6 | 17 | 27 | 56 | -29 | 27 | G19:00 | 30/03/22 | R 24 Valencia CF 2 Villarreal CF 1 B13:00 | 02/04/22 | R 26 Athletic Bilbao 2 Valencia CF 2 M13:00 | 16/04/22 | R 27 Valencia CF 0 FC Barcelona 2 B12:30 | 30/04/22 | R 28 Real Betis Seville 0 Valencia CF 0 B13:00 | 08/05/22 | R 29 Valencia CF 0 Real Madrid 0 M12:30 | 15/05/22 | R 30 SD Eibar 5 Valencia CF 1 |
| 15 | |  SD Eibar | 30 | 7 | 2 | 21 | 35 | 63 | -28 | 23 | M14:00 | 26/03/22 | R 25 Sevilla FC 4 SD Eibar 1 G12:30 | 03/04/22 | R 26 SD Eibar 2 Deportivo Alaves 0 M14:00 | 16/04/22 | R 27 UDG Tenerife 3 SD Eibar 2 B12:30 | 01/05/22 | R 28 SD Eibar 1 Villarreal CF 1 M13:00 | 08/05/22 | R 29 Atletico Madrid 3 SD Eibar 1 G12:30 | 15/05/22 | R 30 SD Eibar 5 Valencia CF 1 |
| 16 | |  Rayo Vallecano | 30 | 3 | 5 | 22 | 27 | 68 | -41 | 14 | M13:00 | 03/04/22 | R 26 Rayo Vallecano 1 UDG Tenerife 2 M12:00 | 17/04/22 | R 27 Rayo Vallecano 3 Levante UD 4 M18:00 | 20/04/22 | R 18 Rayo Vallecano 0 Real Madrid 1 M13:00 | 01/05/22 | R 28 Real Sociedad San Sebastian 4 Rayo Vallecano 0 M17:00 | 08/05/22 | R 29 Rayo Vallecano 1 FC Barcelona 6 G12:30 | 14/05/22 | R 30 Real Betis Seville 1 Rayo Vallecano 3 |
