| 1 | |  FC Shakhtar Donetsk | 18 | 15 | 2 | 1 | 49 | 10 | 39 | 47 | G15:00 | 11/12/21 | R 18  FC Oleksandriya 1 FC Shakhtar Donetsk 2 G18:00 | 03/12/21 | R 17 FC Shakhtar Donetsk 6 FC Lviv 1 G15:00 | 28/11/21 | R 16 FC Ingulets Petrove 0 FC Shakhtar Donetsk 1 G18:00 | 20/11/21 | R 15 FC Shakhtar Donetsk 2 FC Rukh Lviv 0 G18:00 | 07/11/21 | R 14 Kolos Kovalivka 1 FC Shakhtar Donetsk 3 G17:00 | 30/10/21 | R 13 FC Shakhtar Donetsk 4 FC Desna Chernihiv 1 |
| 2 | |  FC Dynamo Kyiv | 18 | 14 | 3 | 1 | 47 | 9 | 38 | 45 | B18:00 | 12/12/21 | R 18 FC Dynamo Kyiv 1 FC Zorya Luhansk 1 G15:00 | 04/12/21 | R 17 Veres Rivne 0 FC Dynamo Kyiv 3 G15:00 | 27/11/21 | R 16 FC Minaj 0 FC Dynamo Kyiv 2 G20:30 | 19/11/21 | R 15 FC Chornomorets Odessa 1 FC Dynamo Kyiv 6 M18:00 | 06/11/21 | R 14 FC Dynamo Kyiv 1 FC Vorskla Poltava 2 G14:00 | 30/10/21 | R 13 FC Mariupol 2 FC Dynamo Kyiv 3 |
| 3 | |  SC Dnipro-1 | 18 | 13 | 1 | 4 | 35 | 17 | 18 | 40 | G18:00 | 10/12/21 | R 18 FC Mariupol 0 SC Dnipro-1 3 G20:30 | 06/12/21 | R 17 SC Dnipro-1 3 FC Chornomorets Odessa 1 G20:30 | 27/11/21 | R 16 SC Dnipro-1 5 FC Vorskla Poltava 1 G20:30 | 20/11/21 | R 15 SC Dnipro-1 3 FC Oleksandriya 1 G15:00 | 07/11/21 | R 14 FC Ingulets Petrove 0 SC Dnipro-1 1 G18:00 | 01/11/21 | R 13 SC Dnipro-1 4 FC Minaj 0 |
| 4 | |  FC Zorya Luhansk | 18 | 11 | 3 | 4 | 37 | 19 | 18 | 36 | B18:00 | 12/12/21 | R 18 FC Dynamo Kyiv 1 FC Zorya Luhansk 1 G15:00 | 05/12/21 | R 17 FC Zorya Luhansk 1 FC Ingulets Petrove 0 G20:30 | 29/11/21 | R 16 FC Oleksandriya 0 FC Zorya Luhansk 1 M15:00 | 20/11/21 | R 15 FC Lviv 2 FC Zorya Luhansk 1 G18:00 | 07/11/21 | R 14 FC Zorya Luhansk 3 Veres Rivne 0 G20:30 | 31/10/21 | R 13 FC Metalist 1925 Kharkiv 1 FC Zorya Luhansk 6 |
| 5 | |  FC Vorskla Poltava | 18 | 9 | 6 | 3 | 30 | 18 | 12 | 33 | B20:30 | 11/12/21 | R 18 FC Lviv 1 FC Vorskla Poltava 1 B18:00 | 04/12/21 | R 17 FC Rukh Lviv 0 FC Vorskla Poltava 0 M20:30 | 27/11/21 | R 16 SC Dnipro-1 5 FC Vorskla Poltava 1 G18:00 | 21/11/21 | R 15 FC Vorskla Poltava 5 FC Mariupol 1 G18:00 | 06/11/21 | R 14 FC Dynamo Kyiv 1 FC Vorskla Poltava 2 B20:30 | 01/11/21 | R 13 FC Vorskla Poltava 0 FC Chornomorets Odessa 0 |
| 6 | |  FC Oleksandriya | 18 | 7 | 5 | 6 | 19 | 16 | 3 | 26 | M15:00 | 11/12/21 | R 18 FC Oleksandriya 1 FC Shakhtar Donetsk 2 G18:00 | 05/12/21 | R 17 FC Oleksandriya 3 FC Minaj 0 M20:30 | 29/11/21 | R 16 FC Oleksandriya 0 FC Zorya Luhansk 1 M20:30 | 20/11/21 | R 15 SC Dnipro-1 3 FC Oleksandriya 1 G20:30 | 05/11/21 | R 14 FC Oleksandriya 2 FC Metalist 1925 Kharkiv 0 B18:00 | 31/10/21 | R 13 FC Rukh Lviv 0 FC Oleksandriya 0 |
| 7 | |  FC Desna Chernihiv | 18 | 7 | 4 | 7 | 22 | 27 | -5 | 25 | M20:30 | 10/12/21 | R 18 FC Ingulets Petrove 2 FC Desna Chernihiv 1 B20:30 | 05/12/21 | R 17 FC Desna Chernihiv 3 FC Mariupol 3 G18:00 | 27/11/21 | R 16 FC Chornomorets Odessa 0 FC Desna Chernihiv 1 M20:30 | 21/11/21 | R 15 FC Desna Chernihiv 0 Kolos Kovalivka 1 G20:30 | 07/11/21 | R 14 FC Lviv 0 FC Desna Chernihiv 2 M17:00 | 30/10/21 | R 13 FC Shakhtar Donetsk 4 FC Desna Chernihiv 1 |
| 8 | |  Kolos Kovalivka | 18 | 7 | 3 | 8 | 14 | 23 | -9 | 24 | G20:30 | 12/12/21 | R 18 Kolos Kovalivka 2 FC Minaj 1 G20:30 | 04/12/21 | R 17 FC Metalist 1925 Kharkiv 0 Kolos Kovalivka 1 G20:30 | 28/11/21 | R 16 Kolos Kovalivka 1 Veres Rivne 0 B15:00 | 24/11/21 | R 3 FC Minaj 1 Kolos Kovalivka 1 G20:30 | 21/11/21 | R 15 FC Desna Chernihiv 0 Kolos Kovalivka 1 M18:00 | 07/11/21 | R 14 Kolos Kovalivka 1 FC Shakhtar Donetsk 3 |
| 9 | |  Veres Rivne | 18 | 6 | 5 | 7 | 15 | 20 | -5 | 23 | B18:00 | 11/12/21 | R 18 Veres Rivne 1 FC Rukh Lviv 1 M15:00 | 04/12/21 | R 17 Veres Rivne 0 FC Dynamo Kyiv 3 M20:30 | 28/11/21 | R 16 Kolos Kovalivka 1 Veres Rivne 0 G20:30 | 22/11/21 | R 15 Veres Rivne 2 FC Metalist 1925 Kharkiv 0 M18:00 | 07/11/21 | R 14 FC Zorya Luhansk 3 Veres Rivne 0 B19:30 | 30/10/21 | R 13 FC Ingulets Petrove 0 Veres Rivne 0 |
| 10 | |  FC Metalist 1925 Kharkiv | 18 | 6 | 1 | 11 | 17 | 29 | -12 | 19 | M15:00 | 12/12/21 | R 18 FC Chornomorets Odessa 2 FC Metalist 1925 Kharkiv 1 M20:30 | 04/12/21 | R 17 FC Metalist 1925 Kharkiv 0 Kolos Kovalivka 1 M18:00 | 28/11/21 | R 16 FC Rukh Lviv 2 FC Metalist 1925 Kharkiv 0 M20:30 | 22/11/21 | R 15 Veres Rivne 2 FC Metalist 1925 Kharkiv 0 M20:30 | 05/11/21 | R 14 FC Oleksandriya 2 FC Metalist 1925 Kharkiv 0 M20:30 | 31/10/21 | R 13 FC Metalist 1925 Kharkiv 1 FC Zorya Luhansk 6 |
| 11 | |  FC Rukh Lviv | 17 | 4 | 6 | 7 | 16 | 21 | -5 | 18 | B18:00 | 11/12/21 | R 18 Veres Rivne 1 FC Rukh Lviv 1 B18:00 | 04/12/21 | R 17 FC Rukh Lviv 0 FC Vorskla Poltava 0 G18:00 | 28/11/21 | R 16 FC Rukh Lviv 2 FC Metalist 1925 Kharkiv 0 M18:00 | 20/11/21 | R 15 FC Shakhtar Donetsk 2 FC Rukh Lviv 0 M20:30 | 06/11/21 | R 14 FC Chornomorets Odessa 4 FC Rukh Lviv 3 B18:00 | 31/10/21 | R 13 FC Rukh Lviv 0 FC Oleksandriya 0 |
| 12 | |  FC Lviv | 18 | 4 | 5 | 9 | 14 | 30 | -16 | 17 | B20:30 | 11/12/21 | R 18 FC Lviv 1 FC Vorskla Poltava 1 M18:00 | 03/12/21 | R 17 FC Shakhtar Donetsk 6 FC Lviv 1 G20:30 | 26/11/21 | R 16 FC Mariupol 0 FC Lviv 1 G15:00 | 20/11/21 | R 15 FC Lviv 2 FC Zorya Luhansk 1 M20:30 | 07/11/21 | R 14 FC Lviv 0 FC Desna Chernihiv 2 G15:00 | 31/10/21 | R 13 Kolos Kovalivka 0 FC Lviv 1 |
| 13 | |  FC Chornomorets Odessa | 18 | 3 | 5 | 10 | 20 | 40 | -20 | 14 | G15:00 | 12/12/21 | R 18 FC Chornomorets Odessa 2 FC Metalist 1925 Kharkiv 1 M20:30 | 06/12/21 | R 17 SC Dnipro-1 3 FC Chornomorets Odessa 1 M18:00 | 27/11/21 | R 16 FC Chornomorets Odessa 0 FC Desna Chernihiv 1 M20:30 | 19/11/21 | R 15 FC Chornomorets Odessa 1 FC Dynamo Kyiv 6 G20:30 | 06/11/21 | R 14 FC Chornomorets Odessa 4 FC Rukh Lviv 3 B20:30 | 01/11/21 | R 13 FC Vorskla Poltava 0 FC Chornomorets Odessa 0 |
| 14 | |  FC Ingulets Petrove | 17 | 3 | 4 | 10 | 13 | 28 | -15 | 13 | G20:30 | 10/12/21 | R 18 FC Ingulets Petrove 2 FC Desna Chernihiv 1 M15:00 | 05/12/21 | R 17 FC Zorya Luhansk 1 FC Ingulets Petrove 0 M15:00 | 28/11/21 | R 16 FC Ingulets Petrove 0 FC Shakhtar Donetsk 1 B15:00 | 21/11/21 | R 15 FC Minaj 2 FC Ingulets Petrove 2 M15:00 | 07/11/21 | R 14 FC Ingulets Petrove 0 SC Dnipro-1 1 B19:30 | 30/10/21 | R 13 FC Ingulets Petrove 0 Veres Rivne 0 |
| 15 | |  FC Minaj | 18 | 1 | 7 | 10 | 12 | 30 | -18 | 10 | M20:30 | 12/12/21 | R 18 Kolos Kovalivka 2 FC Minaj 1 M18:00 | 05/12/21 | R 17 FC Oleksandriya 3 FC Minaj 0 M15:00 | 27/11/21 | R 16 FC Minaj 0 FC Dynamo Kyiv 2 B15:00 | 24/11/21 | R 3 FC Minaj 1 Kolos Kovalivka 1 B15:00 | 21/11/21 | R 15 FC Minaj 2 FC Ingulets Petrove 2 M15:00 | 06/11/21 | R 14 FC Minaj 0 FC Mariupol 2 |
| 16 | |  FC Mariupol | 18 | 2 | 2 | 14 | 21 | 44 | -23 | 8 | M18:00 | 10/12/21 | R 18 FC Mariupol 0 SC Dnipro-1 3 B20:30 | 05/12/21 | R 17 FC Desna Chernihiv 3 FC Mariupol 3 M20:30 | 26/11/21 | R 16 FC Mariupol 0 FC Lviv 1 M18:00 | 21/11/21 | R 15 FC Vorskla Poltava 5 FC Mariupol 1 G15:00 | 06/11/21 | R 14 FC Minaj 0 FC Mariupol 2 M14:00 | 30/10/21 | R 13 FC Mariupol 2 FC Dynamo Kyiv 3 |
