| 1 | |  Manchester City FC | 38 | 29 | 6 | 3 | 99 | 26 | 73 | 93 | G18:00 | 22/05/22 | R 38  Manchester City FC 3 Aston Villa 2 B16:00 | 15/05/22 | R 37 West Ham United FC 2 Manchester City FC 2 G22:15 | 11/05/22 | R 33 Wolverhampton Wanderers FC 1 Manchester City FC 5 G18:30 | 08/05/22 | R 36 Manchester City FC 5 Newcastle United FC 0 G19:30 | 30/04/22 | R 35 Leeds United 0 Manchester City FC 4 G17:00 | 23/04/22 | R 34 Manchester City FC 5 Watford 1 |
| 2 | |  Liverpool | 38 | 28 | 8 | 2 | 94 | 26 | 68 | 92 | G18:00 | 22/05/22 | R 38 Liverpool 3 Wolverhampton Wanderers FC 1 G21:45 | 17/05/22 | R 37 Southampton 1 Liverpool 2 G22:00 | 10/05/22 | R 33 Aston Villa 1 Liverpool 2 B21:45 | 07/05/22 | R 36 Liverpool 1 Tottenham 1 G14:30 | 30/04/22 | R 35 Newcastle United FC 0 Liverpool 1 G18:30 | 24/04/22 | R 34 Liverpool 2 Everton FC 0 |
| 3 | |  Chelsea | 38 | 21 | 11 | 6 | 76 | 33 | 43 | 74 | G18:00 | 22/05/22 | R 38 Chelsea 2 Watford 1 B22:00 | 19/05/22 | R 27 Chelsea 1 Leicester City FC 1 G21:30 | 11/05/22 | R 33 Leeds United 0 Chelsea 3 B17:00 | 07/05/22 | R 36 Chelsea 2 Wolverhampton Wanderers FC 2 M16:00 | 01/05/22 | R 35 Everton FC 1 Chelsea 0 B21:45 | 28/04/22 | R 37 Manchester United FC 1 Chelsea 1 |
| 4 | |  Tottenham | 38 | 22 | 5 | 11 | 69 | 40 | 29 | 71 | G18:00 | 22/05/22 | R 38 Norwich City FC 0 Tottenham 5 G14:00 | 15/05/22 | R 37 Tottenham 1 Burnley 0 G21:45 | 12/05/22 | R 22 Tottenham 3 Arsenal FC 0 B21:45 | 07/05/22 | R 36 Liverpool 1 Tottenham 1 G16:00 | 01/05/22 | R 35 Tottenham 3 Leicester City FC 1 B19:30 | 23/04/22 | R 34 Brentford 0 Tottenham 0 |
| 5 | |  Arsenal FC | 38 | 22 | 3 | 13 | 61 | 48 | 13 | 69 | G18:00 | 22/05/22 | R 38 Arsenal FC 5 Everton FC 1 M22:00 | 16/05/22 | R 37 Newcastle United FC 2 Arsenal FC 0 M21:45 | 12/05/22 | R 22 Tottenham 3 Arsenal FC 0 G16:00 | 08/05/22 | R 36 Arsenal FC 2 Leeds United 1 G18:30 | 01/05/22 | R 35 West Ham United FC 1 Arsenal FC 2 G14:30 | 23/04/22 | R 34 Arsenal FC 3 Manchester United FC 1 |
| 6 | |  Manchester United FC | 38 | 16 | 10 | 12 | 57 | 57 | 0 | 58 | M18:00 | 22/05/22 | R 38 Crystal Palace FC 1 Manchester United FC 0 M19:30 | 07/05/22 | R 36 Brighton & Hove Albion FC 4 Manchester United FC 0 G22:00 | 02/05/22 | R 35 Manchester United FC 3 Brentford 0 B21:45 | 28/04/22 | R 37 Manchester United FC 1 Chelsea 1 M14:30 | 23/04/22 | R 34 Arsenal FC 3 Manchester United FC 1 M22:00 | 19/04/22 | R 30 Liverpool 4 Manchester United FC 0 |
| 7 | |  West Ham United FC | 38 | 16 | 8 | 14 | 60 | 51 | 9 | 56 | M18:00 | 22/05/22 | R 38 Brighton & Hove Albion FC 3 West Ham United FC 1 B16:00 | 15/05/22 | R 37 West Ham United FC 2 Manchester City FC 2 G16:00 | 08/05/22 | R 36 Norwich City FC 0 West Ham United FC 4 M18:30 | 01/05/22 | R 35 West Ham United FC 1 Arsenal FC 2 M16:00 | 24/04/22 | R 34 Chelsea 1 West Ham United FC 0 B16:15 | 17/04/22 | R 33 West Ham United FC 1 Burnley 1 |
| 8 | |  Leicester City FC | 38 | 14 | 10 | 14 | 62 | 59 | 3 | 52 | G18:00 | 22/05/22 | R 38 Leicester City FC 4 Southampton 1 B22:00 | 19/05/22 | R 27 Chelsea 1 Leicester City FC 1 G16:00 | 15/05/22 | R 37 Watford 1 Leicester City FC 5 G21:45 | 11/05/22 | R 21 Leicester City FC 3 Norwich City FC 0 M16:00 | 08/05/22 | R 36 Leicester City FC 1 Everton FC 2 M16:00 | 01/05/22 | R 35 Tottenham 3 Leicester City FC 1 |
| 9 | |  Brighton & Hove Albion FC | 38 | 12 | 15 | 11 | 42 | 44 | -2 | 51 | G18:00 | 22/05/22 | R 38 Brighton & Hove Albion FC 3 West Ham United FC 1 B16:00 | 15/05/22 | R 37 Leeds United 1 Brighton & Hove Albion FC 1 G19:30 | 07/05/22 | R 36 Brighton & Hove Albion FC 4 Manchester United FC 0 G17:00 | 30/04/22 | R 35 Wolverhampton Wanderers FC 0 Brighton & Hove Albion FC 3 B16:00 | 24/04/22 | R 34 Brighton & Hove Albion FC 2 Southampton 2 M22:00 | 20/04/22 | R 30 Manchester City FC 3 Brighton & Hove Albion FC 0 |
| 10 | |  Wolverhampton Wanderers FC | 38 | 15 | 6 | 17 | 38 | 43 | -5 | 51 | M18:00 | 22/05/22 | R 38 Liverpool 3 Wolverhampton Wanderers FC 1 B16:00 | 15/05/22 | R 37 Wolverhampton Wanderers FC 1 Norwich City FC 1 M22:15 | 11/05/22 | R 33 Wolverhampton Wanderers FC 1 Manchester City FC 5 B17:00 | 07/05/22 | R 36 Chelsea 2 Wolverhampton Wanderers FC 2 M17:00 | 30/04/22 | R 35 Wolverhampton Wanderers FC 0 Brighton & Hove Albion FC 3 M16:00 | 24/04/22 | R 34 Burnley 1 Wolverhampton Wanderers FC 0 |
| 11 | |  Newcastle United FC | 38 | 13 | 10 | 15 | 44 | 62 | -18 | 49 | G18:00 | 22/05/22 | R 38 Burnley 1 Newcastle United FC 2 G22:00 | 16/05/22 | R 37 Newcastle United FC 2 Arsenal FC 0 M18:30 | 08/05/22 | R 36 Manchester City FC 5 Newcastle United FC 0 M14:30 | 30/04/22 | R 35 Newcastle United FC 0 Liverpool 1 G17:00 | 23/04/22 | R 34 Norwich City FC 0 Newcastle United FC 3 G21:45 | 20/04/22 | R 30 Newcastle United FC 1 Crystal Palace FC 0 |
| 12 | |  Crystal Palace FC | 38 | 11 | 15 | 12 | 50 | 46 | 4 | 48 | G18:00 | 22/05/22 | R 38 Crystal Palace FC 1 Manchester United FC 0 M21:45 | 19/05/22 | R 33 Everton FC 3 Crystal Palace FC 2 B16:00 | 15/05/22 | R 37 Aston Villa 1 Crystal Palace FC 1 G17:00 | 07/05/22 | R 36 Crystal Palace FC 1 Watford 0 G17:00 | 30/04/22 | R 35 Southampton 1 Crystal Palace FC 2 B22:00 | 25/04/22 | R 34 Crystal Palace FC 0 Leeds United 0 |
| 13 | |  Brentford | 38 | 13 | 7 | 18 | 48 | 56 | -8 | 46 | M18:00 | 22/05/22 | R 38 Brentford 1 Leeds United 2 G18:30 | 15/05/22 | R 37 Everton FC 2 Brentford 3 G17:00 | 07/05/22 | R 36 Brentford 3 Southampton 0 M22:00 | 02/05/22 | R 35 Manchester United FC 3 Brentford 0 B19:30 | 23/04/22 | R 34 Brentford 0 Tottenham 0 G17:00 | 16/04/22 | R 33 Watford 1 Brentford 2 |
| 14 | |  Aston Villa | 38 | 13 | 6 | 19 | 52 | 54 | -2 | 45 | M18:00 | 22/05/22 | R 38 Manchester City FC 3 Aston Villa 2 B22:00 | 19/05/22 | R 18 Aston Villa 1 Burnley 1 B16:00 | 15/05/22 | R 37 Aston Villa 1 Crystal Palace FC 1 M22:00 | 10/05/22 | R 33 Aston Villa 1 Liverpool 2 G17:00 | 07/05/22 | R 36 Burnley 1 Aston Villa 3 G17:00 | 30/04/22 | R 35 Aston Villa 2 Norwich City FC 0 |
| 15 | |  Southampton | 38 | 9 | 13 | 16 | 43 | 67 | -24 | 40 | M18:00 | 22/05/22 | R 38 Leicester City FC 4 Southampton 1 M21:45 | 17/05/22 | R 37 Southampton 1 Liverpool 2 M17:00 | 07/05/22 | R 36 Brentford 3 Southampton 0 M17:00 | 30/04/22 | R 35 Southampton 1 Crystal Palace FC 2 B16:00 | 24/04/22 | R 34 Brighton & Hove Albion FC 2 Southampton 2 M21:45 | 21/04/22 | R 30 Burnley 2 Southampton 0 |
| 16 | |  Everton FC | 38 | 11 | 6 | 21 | 43 | 66 | -23 | 39 | M18:00 | 22/05/22 | R 38 Arsenal FC 5 Everton FC 1 G21:45 | 19/05/22 | R 33 Everton FC 3 Crystal Palace FC 2 M18:30 | 15/05/22 | R 37 Everton FC 2 Brentford 3 B21:45 | 11/05/22 | R 30 Watford 0 Everton FC 0 G16:00 | 08/05/22 | R 36 Leicester City FC 1 Everton FC 2 G16:00 | 01/05/22 | R 35 Everton FC 1 Chelsea 0 |
| 17 | |  Leeds United | 38 | 9 | 11 | 18 | 42 | 79 | -37 | 38 | G18:00 | 22/05/22 | R 38 Brentford 1 Leeds United 2 B16:00 | 15/05/22 | R 37 Leeds United 1 Brighton & Hove Albion FC 1 M21:30 | 11/05/22 | R 33 Leeds United 0 Chelsea 3 M16:00 | 08/05/22 | R 36 Arsenal FC 2 Leeds United 1 M19:30 | 30/04/22 | R 35 Leeds United 0 Manchester City FC 4 B22:00 | 25/04/22 | R 34 Crystal Palace FC 0 Leeds United 0 |
| 18 | |  Burnley | 38 | 7 | 14 | 17 | 34 | 53 | -19 | 35 | M18:00 | 22/05/22 | R 38 Burnley 1 Newcastle United FC 2 B22:00 | 19/05/22 | R 18 Aston Villa 1 Burnley 1 M14:00 | 15/05/22 | R 37 Tottenham 1 Burnley 0 M17:00 | 07/05/22 | R 36 Burnley 1 Aston Villa 3 G17:00 | 30/04/22 | R 35 Watford 1 Burnley 2 G16:00 | 24/04/22 | R 34 Burnley 1 Wolverhampton Wanderers FC 0 |
| 19 | |  Watford | 38 | 6 | 5 | 27 | 34 | 77 | -43 | 23 | M18:00 | 22/05/22 | R 38 Chelsea 2 Watford 1 M16:00 | 15/05/22 | R 37 Watford 1 Leicester City FC 5 B21:45 | 11/05/22 | R 30 Watford 0 Everton FC 0 M17:00 | 07/05/22 | R 36 Crystal Palace FC 1 Watford 0 M17:00 | 30/04/22 | R 35 Watford 1 Burnley 2 M17:00 | 23/04/22 | R 34 Manchester City FC 5 Watford 1 |
| 20 | |  Norwich City FC | 38 | 5 | 7 | 26 | 23 | 84 | -61 | 22 | M18:00 | 22/05/22 | R 38 Norwich City FC 0 Tottenham 5 B16:00 | 15/05/22 | R 37 Wolverhampton Wanderers FC 1 Norwich City FC 1 M21:45 | 11/05/22 | R 21 Leicester City FC 3 Norwich City FC 0 M16:00 | 08/05/22 | R 36 Norwich City FC 0 West Ham United FC 4 M17:00 | 30/04/22 | R 35 Aston Villa 2 Norwich City FC 0 M17:00 | 23/04/22 | R 34 Norwich City FC 0 Newcastle United FC 3 |
