| 1 | |  FK Zenit St Petersburg | 30 | 20 | 8 | 2 | 61 | 21 | 40 | 68 | B13:00 | 28/11/10 | R 30  FK Zenit St Petersburg 0 PFK Krylia Sovyetov Samara 0 B13:00 | 20/11/10 | R 29 FK Rubin Kazan 2 FK Zenit St Petersburg 2 G14:00 | 14/11/10 | R 28 FK Zenit St Petersburg 5 FK Rostov 0 M18:00 | 10/11/10 | R 18 FK Zenit St Petersburg 1 CSKA Moskova 3 G13:00 | 07/11/10 | R 27 FC Sibir Novosibirsk 2 FK Zenit St Petersburg 5 G13:00 | 31/10/10 | R 26 FK Zenit St Petersburg 3 FC Spartak Vladikavkaz 0 |
| 2 | |  CSKA Moskova | 30 | 18 | 8 | 4 | 51 | 22 | 29 | 62 | B13:00 | 28/11/10 | R 30 Amkar Perm 0 CSKA Moskova 0 G13:00 | 20/11/10 | R 29 CSKA Moskova 3 FK Spartak Moskova 1 B13:00 | 14/11/10 | R 28 Spartak Nalchik 1 CSKA Moskova 1 G18:00 | 10/11/10 | R 18 FK Zenit St Petersburg 1 CSKA Moskova 3 G18:00 | 07/11/10 | R 27 CSKA Moskova 4 PFK Krylia Sovyetov Samara 3 B17:30 | 31/10/10 | R 26 Saturn Ramenskoye 1 CSKA Moskova 1 |
| 3 | |  FK Rubin Kazan | 30 | 15 | 13 | 2 | 37 | 16 | 21 | 58 | B13:00 | 28/11/10 | R 30 FK Lokomotiv Moskova 0 FK Rubin Kazan 0 B13:00 | 20/11/10 | R 29 FK Rubin Kazan 2 FK Zenit St Petersburg 2 B18:00 | 13/11/10 | R 28 FK Dinamo Moscow 2 FK Rubin Kazan 2 B18:00 | 08/11/10 | R 27 FK Rubin Kazan 1 FK Spartak Moskova 1 G17:45 | 29/10/10 | R 26 PFK Krylia Sovyetov Samara 0 FK Rubin Kazan 2 B13:10 | 24/10/10 | R 25 CSKA Moskova 0 FK Rubin Kazan 0 |
| 4 | |  FK Spartak Moskova | 30 | 13 | 10 | 7 | 43 | 33 | 10 | 49 | B13:00 | 28/11/10 | R 30 FK Dinamo Moscow 1 FK Spartak Moskova 1 M13:00 | 20/11/10 | R 29 CSKA Moskova 3 FK Spartak Moskova 1 B18:00 | 14/11/10 | R 28 FK Spartak Moskova 0 PFK Krylia Sovyetov Samara 0 B18:00 | 08/11/10 | R 27 FK Rubin Kazan 1 FK Spartak Moskova 1 G18:30 | 30/10/10 | R 26 FK Spartak Moskova 2 FK Rostov 1 G19:30 | 27/10/10 | R 16 FK Spartak Moskova 1 FK Zenit St Petersburg 0 |
| 5 | |  FK Lokomotiv Moskova | 30 | 13 | 9 | 8 | 34 | 29 | 5 | 48 | B13:00 | 28/11/10 | R 30 FK Lokomotiv Moskova 0 FK Rubin Kazan 0 G13:00 | 20/11/10 | R 29 FK Rostov 1 FK Lokomotiv Moskova 2 B15:15 | 14/11/10 | R 28 FK Lokomotiv Moskova 1 FC Sibir Novosibirsk 1 B15:30 | 07/11/10 | R 27 FC Spartak Vladikavkaz 0 FK Lokomotiv Moskova 0 G15:15 | 31/10/10 | R 26 FC Anzhi Makhachkala 0 FK Lokomotiv Moskova 1 G11:00 | 24/10/10 | R 25 Amkar Perm 1 FK Lokomotiv Moskova 2 |
| 6 | |  Spartak Nalchik | 30 | 12 | 8 | 10 | 40 | 37 | 3 | 44 | M13:00 | 28/11/10 | R 30 Spartak Nalchik 1 FC Anzhi Makhachkala 3 M13:00 | 20/11/10 | R 29 Amkar Perm 3 Spartak Nalchik 1 B13:00 | 14/11/10 | R 28 Spartak Nalchik 1 CSKA Moskova 1 G15:00 | 05/11/10 | R 27 Spartak Nalchik 2 Saturn Ramenskoye 0 B13:00 | 31/10/10 | R 26 RFK Akhmat Grozny 1 Spartak Nalchik 1 G15:15 | 23/10/10 | R 25 Spartak Nalchik 2 FC Tom Tomsk 1 |
| 7 | |  FK Dinamo Moscow | 30 | 9 | 13 | 8 | 38 | 31 | 7 | 40 | B13:00 | 28/11/10 | R 30 FK Dinamo Moscow 1 FK Spartak Moskova 1 M13:00 | 20/11/10 | R 29 PFK Krylia Sovyetov Samara 1 FK Dinamo Moscow 0 B18:00 | 13/11/10 | R 28 FK Dinamo Moscow 2 FK Rubin Kazan 2 B17:30 | 06/11/10 | R 27 FK Rostov 1 FK Dinamo Moscow 1 G16:00 | 30/10/10 | R 26 FK Dinamo Moscow 4 FC Sibir Novosibirsk 1 B17:15 | 27/10/10 | R 16 FK Dinamo Moscow 0 CSKA Moskova 0 |
| 8 | |  FC Tom Tomsk | 30 | 10 | 7 | 13 | 35 | 43 | -8 | 37 | G13:00 | 28/11/10 | R 30 FC Tom Tomsk 3 FK Rostov 1 G13:00 | 20/11/10 | R 29 FC Sibir Novosibirsk 0 FC Tom Tomsk 1 B13:30 | 13/11/10 | R 28 FC Tom Tomsk 1 FC Spartak Vladikavkaz 1 M15:15 | 06/11/10 | R 27 FC Anzhi Makhachkala 1 FC Tom Tomsk 0 G10:45 | 31/10/10 | R 26 FC Tom Tomsk 1 Amkar Perm 0 M15:15 | 23/10/10 | R 25 Spartak Nalchik 2 FC Tom Tomsk 1 |
| 9 | |  FK Rostov | 30 | 10 | 4 | 16 | 27 | 44 | -17 | 34 | M13:00 | 28/11/10 | R 30 FC Tom Tomsk 3 FK Rostov 1 M13:00 | 20/11/10 | R 29 FK Rostov 1 FK Lokomotiv Moskova 2 M14:00 | 14/11/10 | R 28 FK Zenit St Petersburg 5 FK Rostov 0 B17:30 | 06/11/10 | R 27 FK Rostov 1 FK Dinamo Moscow 1 M18:30 | 30/10/10 | R 26 FK Spartak Moskova 2 FK Rostov 1 M17:45 | 24/10/10 | R 25 FK Rostov 1 PFK Krylia Sovyetov Samara 2 |
| 10 | |  Saturn Ramenskoye | 30 | 8 | 10 | 12 | 27 | 38 | -11 | 34 | B13:00 | 28/11/10 | R 30 Saturn Ramenskoye 1 FC Spartak Vladikavkaz 1 G13:00 | 20/11/10 | R 29 FC Anzhi Makhachkala 1 Saturn Ramenskoye 2 B17:00 | 12/11/10 | R 28 Saturn Ramenskoye 2 Amkar Perm 2 M15:00 | 05/11/10 | R 27 Spartak Nalchik 2 Saturn Ramenskoye 0 B17:30 | 31/10/10 | R 26 Saturn Ramenskoye 1 CSKA Moskova 1 G17:30 | 23/10/10 | R 25 Saturn Ramenskoye 1 RFK Akhmat Grozny 0 |
| 11 | |  FC Anzhi Makhachkala | 30 | 9 | 6 | 15 | 29 | 39 | -10 | 33 | G13:00 | 28/11/10 | R 30 Spartak Nalchik 1 FC Anzhi Makhachkala 3 M13:00 | 20/11/10 | R 29 FC Anzhi Makhachkala 1 Saturn Ramenskoye 2 G15:45 | 13/11/10 | R 28 RFK Akhmat Grozny 1 FC Anzhi Makhachkala 3 G15:15 | 06/11/10 | R 27 FC Anzhi Makhachkala 1 FC Tom Tomsk 0 M15:15 | 31/10/10 | R 26 FC Anzhi Makhachkala 0 FK Lokomotiv Moskova 1 B15:30 | 24/10/10 | R 25 FC Anzhi Makhachkala 3 FK Zenit St Petersburg 3 |
| 12 | |  RFK Akhmat Grozny | 30 | 8 | 9 | 13 | 28 | 34 | -6 | 33 | B13:00 | 28/11/10 | R 30 RFK Akhmat Grozny 1 FC Sibir Novosibirsk 1 M13:00 | 20/11/10 | R 29 FC Spartak Vladikavkaz 2 RFK Akhmat Grozny 1 M15:45 | 13/11/10 | R 28 RFK Akhmat Grozny 1 FC Anzhi Makhachkala 3 M13:00 | 06/11/10 | R 27 Amkar Perm 2 RFK Akhmat Grozny 0 B13:00 | 31/10/10 | R 26 RFK Akhmat Grozny 1 Spartak Nalchik 1 M17:30 | 23/10/10 | R 25 Saturn Ramenskoye 1 RFK Akhmat Grozny 0 |
| 13 | |  PFK Krylia Sovyetov Samara | 30 | 7 | 10 | 13 | 28 | 40 | -12 | 31 | B13:00 | 28/11/10 | R 30 FK Zenit St Petersburg 0 PFK Krylia Sovyetov Samara 0 G13:00 | 20/11/10 | R 29 PFK Krylia Sovyetov Samara 1 FK Dinamo Moscow 0 B18:00 | 14/11/10 | R 28 FK Spartak Moskova 0 PFK Krylia Sovyetov Samara 0 M18:00 | 07/11/10 | R 27 CSKA Moskova 4 PFK Krylia Sovyetov Samara 3 M17:45 | 29/10/10 | R 26 PFK Krylia Sovyetov Samara 0 FK Rubin Kazan 2 G17:45 | 24/10/10 | R 25 FK Rostov 1 PFK Krylia Sovyetov Samara 2 |
| 14 | |  Amkar Perm | 30 | 8 | 6 | 16 | 24 | 35 | -11 | 30 | B13:00 | 28/11/10 | R 30 Amkar Perm 0 CSKA Moskova 0 G13:00 | 20/11/10 | R 29 Amkar Perm 3 Spartak Nalchik 1 B17:00 | 12/11/10 | R 28 Saturn Ramenskoye 2 Amkar Perm 2 G13:00 | 06/11/10 | R 27 Amkar Perm 2 RFK Akhmat Grozny 0 M10:45 | 31/10/10 | R 26 FC Tom Tomsk 1 Amkar Perm 0 M11:00 | 24/10/10 | R 25 Amkar Perm 1 FK Lokomotiv Moskova 2 |
| 15 | |  FC Spartak Vladikavkaz | 30 | 7 | 9 | 14 | 25 | 41 | -16 | 30 | B13:00 | 28/11/10 | R 30 Saturn Ramenskoye 1 FC Spartak Vladikavkaz 1 G13:00 | 20/11/10 | R 29 FC Spartak Vladikavkaz 2 RFK Akhmat Grozny 1 B13:30 | 13/11/10 | R 28 FC Tom Tomsk 1 FC Spartak Vladikavkaz 1 B15:30 | 07/11/10 | R 27 FC Spartak Vladikavkaz 0 FK Lokomotiv Moskova 0 M13:00 | 31/10/10 | R 26 FK Zenit St Petersburg 3 FC Spartak Vladikavkaz 0 B13:00 | 23/10/10 | R 25 FC Spartak Vladikavkaz 0 FK Dinamo Moscow 0 |
| 16 | |  FC Sibir Novosibirsk | 30 | 4 | 8 | 18 | 34 | 58 | -24 | 20 | B13:00 | 28/11/10 | R 30 RFK Akhmat Grozny 1 FC Sibir Novosibirsk 1 M13:00 | 20/11/10 | R 29 FC Sibir Novosibirsk 0 FC Tom Tomsk 1 B15:15 | 14/11/10 | R 28 FK Lokomotiv Moskova 1 FC Sibir Novosibirsk 1 M13:00 | 07/11/10 | R 27 FC Sibir Novosibirsk 2 FK Zenit St Petersburg 5 M16:00 | 30/10/10 | R 26 FK Dinamo Moscow 4 FC Sibir Novosibirsk 1 B10:45 | 23/10/10 | R 25 FC Sibir Novosibirsk 0 FK Spartak Moskova 0 |
