| 1 | |  CF Tigres UANL | 17 | 12 | 4 | 1 | 39 | 12 | 27 | 40 | G18:00 | 07/05/21 | R quarterfinal  Club America 0 CF Tigres UANL 4 G04:00 | 11/05/21 | R quarterfinal CF Tigres UANL 2 Club America 0 B05:05 | 15/05/21 | R semifinal CF Monterrey 2 CF Tigres UANL 2 G03:00 | 18/05/21 | R semifinal CF Tigres UANL 4 CF Monterrey 1 G05:00 | 25/05/21 | R final CD Guadalajara 1 CF Tigres UANL 2 G03:00 | 01/06/21 | R final CF Tigres UANL 5 CD Guadalajara 3 |
| 2 | |  CD Guadalajara | 17 | 11 | 3 | 3 | 44 | 19 | 25 | 36 | G00:00 | 08/05/21 | R quarterfinal Deportivo Toluca FC 0 CD Guadalajara 1 G02:00 | 11/05/21 | R quarterfinal CD Guadalajara 3 Deportivo Toluca FC 0 B01:00 | 15/05/21 | R semifinal Atlas FC 0 CD Guadalajara 0 G05:00 | 18/05/21 | R semifinal CD Guadalajara 2 Atlas FC 1 M05:00 | 25/05/21 | R final CD Guadalajara 1 CF Tigres UANL 2 M03:00 | 01/06/21 | R final CF Tigres UANL 5 CD Guadalajara 3 |
| 3 | |  Atlas FC | 17 | 10 | 4 | 3 | 30 | 23 | 7 | 34 | B20:00 | 24/04/21 | R 16 Pumas Unam 1 Atlas FC 1 M05:00 | 04/05/21 | R 17 CF Monterrey 3 Atlas FC 1 G02:30 | 08/05/21 | R quarterfinal CF Pachuca 0 Atlas FC 2 G00:00 | 11/05/21 | R quarterfinal Atlas FC 3 CF Pachuca 1 B01:00 | 15/05/21 | R semifinal Atlas FC 0 CD Guadalajara 0 M05:00 | 18/05/21 | R semifinal CD Guadalajara 2 Atlas FC 1 |
| 4 | |  CF Monterrey | 17 | 10 | 3 | 4 | 40 | 22 | 18 | 33 | M01:00 | 27/04/21 | R 16 CD Guadalajara 5 CF Monterrey 0 G05:00 | 04/05/21 | R 17 CF Monterrey 3 Atlas FC 1 G20:00 | 07/05/21 | R quarterfinal Pumas Unam 1 CF Monterrey 2 G05:30 | 11/05/21 | R quarterfinal CF Monterrey 2 Pumas Unam 1 B05:05 | 15/05/21 | R semifinal CF Monterrey 2 CF Tigres UANL 2 M03:00 | 18/05/21 | R semifinal CF Tigres UANL 4 CF Monterrey 1 |
| 5 | |  Pumas Unam | 17 | 9 | 5 | 3 | 24 | 17 | 7 | 32 | M19:00 | 03/04/21 | R 14 CD Guadalajara 4 Pumas Unam 1 G20:00 | 17/04/21 | R 15 Pumas Unam 3 Queretaro FC 2 B20:00 | 24/04/21 | R 16 Pumas Unam 1 Atlas FC 1 G00:00 | 04/05/21 | R 17 Deportivo Toluca FC 0 Pumas Unam 1 M20:00 | 07/05/21 | R quarterfinal Pumas Unam 1 CF Monterrey 2 M05:30 | 11/05/21 | R quarterfinal CF Monterrey 2 Pumas Unam 1 |
| 6 | |  CF Pachuca | 17 | 9 | 3 | 5 | 24 | 15 | 9 | 30 | G05:00 | 06/04/21 | R 14 CF Pachuca 2 Club Tijuana de Caliente 1 G18:00 | 17/04/21 | R 15 Mazatlan FC 0 CF Pachuca 2 M00:00 | 24/04/21 | R 16 Club Necaxa 1 CF Pachuca 0 G18:00 | 01/05/21 | R 17 CF Pachuca 4 Atletico San Luis 1 M02:30 | 08/05/21 | R quarterfinal CF Pachuca 0 Atlas FC 2 M00:00 | 11/05/21 | R quarterfinal Atlas FC 3 CF Pachuca 1 |
| 7 | |  Deportivo Toluca FC | 17 | 8 | 5 | 4 | 17 | 14 | 3 | 29 | G00:00 | 06/04/21 | R 14 Deportivo Toluca FC 1 Mazatlan FC 0 G00:00 | 20/04/21 | R 15 Deportivo Toluca FC 1 Club Santos Laguna 0 G01:00 | 27/04/21 | R 16 Atletico San Luis 1 Deportivo Toluca FC 2 M00:00 | 04/05/21 | R 17 Deportivo Toluca FC 0 Pumas Unam 1 M00:00 | 08/05/21 | R quarterfinal Deportivo Toluca FC 0 CD Guadalajara 1 M02:00 | 11/05/21 | R quarterfinal CD Guadalajara 3 Deportivo Toluca FC 0 |
| 8 | |  Club America | 17 | 6 | 6 | 5 | 23 | 22 | 1 | 24 | G03:00 | 06/04/21 | R 14 Club Santos Laguna 1 Club America 2 B01:00 | 20/04/21 | R 15 CF Monterrey 1 Club America 1 G20:00 | 25/04/21 | R 16 Club America 2 Cruz Azul 1 M20:00 | 02/05/21 | R 17 Puebla FC 1 Club America 0 M18:00 | 07/05/21 | R quarterfinal Club America 0 CF Tigres UANL 4 M04:00 | 11/05/21 | R quarterfinal CF Tigres UANL 2 Club America 0 |
| 9 | |  Club Santos Laguna | 17 | 6 | 4 | 7 | 26 | 27 | -1 | 22 | B02:00 | 22/03/21 | R 12 Atletico San Luis 2 Club Santos Laguna 2 G01:30 | 30/03/21 | R 13 Club Santos Laguna 2 Cruz Azul 1 M03:00 | 06/04/21 | R 14 Club Santos Laguna 1 Club America 2 M00:00 | 20/04/21 | R 15 Deportivo Toluca FC 1 Club Santos Laguna 0 G03:00 | 27/04/21 | R 16 Club Santos Laguna 3 FC Juarez 0 G18:00 | 01/05/21 | R 17 Mazatlan FC 2 Club Santos Laguna 3 |
| 10 | |  Cruz Azul | 17 | 6 | 4 | 7 | 21 | 26 | -5 | 22 | G19:00 | 18/03/21 | R 12 Cruz Azul 3 Mazatlan FC 0 M01:30 | 30/03/21 | R 13 Club Santos Laguna 2 Cruz Azul 1 M03:00 | 06/04/21 | R 14 CF Tigres UANL 3 Cruz Azul 0 M00:00 | 17/04/21 | R 15 Cruz Azul 0 CD Guadalajara 1 M20:00 | 25/04/21 | R 16 Club America 2 Cruz Azul 1 M20:45 | 30/04/21 | R 17 Cruz Azul 2 Queretaro FC 5 |
| 11 | |  Queretaro FC | 17 | 6 | 1 | 10 | 21 | 27 | -6 | 19 | M02:00 | 20/03/21 | R 12 Queretaro FC 0 Atlas FC 1 M06:00 | 29/03/21 | R 13 FC Juarez 2 Queretaro FC 0 G02:00 | 03/04/21 | R 14 Queretaro FC 1 Club Leon 0 M20:00 | 17/04/21 | R 15 Pumas Unam 3 Queretaro FC 2 G01:00 | 23/04/21 | R 16 Queretaro FC 2 Club Tijuana de Caliente 1 G20:45 | 30/04/21 | R 17 Cruz Azul 2 Queretaro FC 5 |
| 12 | |  Club Tijuana de Caliente | 17 | 5 | 3 | 9 | 17 | 20 | -3 | 18 | M06:00 | 23/03/21 | R 12 Club Tijuana de Caliente 0 CF Monterrey 2 M04:00 | 30/03/21 | R 13 Club Leon 2 Club Tijuana de Caliente 1 M05:00 | 06/04/21 | R 14 CF Pachuca 2 Club Tijuana de Caliente 1 M03:00 | 20/04/21 | R 15 Club Tijuana de Caliente 0 CF Tigres UANL 1 M01:00 | 23/04/21 | R 16 Queretaro FC 2 Club Tijuana de Caliente 1 G05:00 | 04/05/21 | R 17 Club Tijuana de Caliente 3 Club Necaxa 0 |
| 13 | |  Mazatlan FC | 17 | 4 | 6 | 7 | 16 | 25 | -9 | 18 | M19:00 | 18/03/21 | R 12 Cruz Azul 3 Mazatlan FC 0 B04:00 | 27/03/21 | R 13 Mazatlan FC 0 Pumas Unam 0 M00:00 | 06/04/21 | R 14 Deportivo Toluca FC 1 Mazatlan FC 0 M18:00 | 17/04/21 | R 15 Mazatlan FC 0 CF Pachuca 2 B03:00 | 27/04/21 | R 16 CF Tigres UANL 2 Mazatlan FC 2 M18:00 | 01/05/21 | R 17 Mazatlan FC 2 Club Santos Laguna 3 |
| 14 | |  Club Leon | 17 | 5 | 2 | 10 | 17 | 33 | -16 | 17 | M21:00 | 20/03/21 | R 12 Pumas Unam 2 Club Leon 0 G04:00 | 30/03/21 | R 13 Club Leon 2 Club Tijuana de Caliente 1 M02:00 | 03/04/21 | R 14 Queretaro FC 1 Club Leon 0 G00:00 | 20/04/21 | R 15 Club Leon 3 Atletico San Luis 2 G03:00 | 27/04/21 | R 16 Club Leon 2 Puebla FC 1 M18:00 | 02/05/21 | R 17 FC Juarez 2 Club Leon 1 |
| 15 | |  Club Necaxa | 17 | 4 | 4 | 9 | 14 | 29 | -15 | 16 | B21:00 | 22/03/21 | R 12 Deportivo Toluca FC 1 Club Necaxa 1 B01:00 | 27/03/21 | R 13 Club Necaxa 1 Atletico San Luis 1 G01:00 | 03/04/21 | R 14 Club Necaxa 2 FC Juarez 0 M18:00 | 17/04/21 | R 15 Atlas FC 3 Club Necaxa 1 G00:00 | 24/04/21 | R 16 Club Necaxa 1 CF Pachuca 0 M05:00 | 04/05/21 | R 17 Club Tijuana de Caliente 3 Club Necaxa 0 |
| 16 | |  Puebla FC | 17 | 3 | 3 | 11 | 14 | 26 | -12 | 12 | M19:00 | 21/03/21 | R 12 CD Guadalajara 3 Puebla FC 0 M21:00 | 28/03/21 | R 13 Puebla FC 0 CF Pachuca 1 M20:00 | 04/04/21 | R 14 Puebla FC 2 CF Monterrey 3 G03:00 | 20/04/21 | R 15 FC Juarez 1 Puebla FC 2 M03:00 | 27/04/21 | R 16 Club Leon 2 Puebla FC 1 G20:00 | 02/05/21 | R 17 Puebla FC 1 Club America 0 |
| 17 | |  FC Juarez | 17 | 3 | 3 | 11 | 15 | 28 | -13 | 12 | M05:30 | 23/03/21 | R 12 CF Tigres UANL 3 FC Juarez 0 G06:00 | 29/03/21 | R 13 FC Juarez 2 Queretaro FC 0 M01:00 | 03/04/21 | R 14 Club Necaxa 2 FC Juarez 0 M03:00 | 20/04/21 | R 15 FC Juarez 1 Puebla FC 2 M03:00 | 27/04/21 | R 16 Club Santos Laguna 3 FC Juarez 0 G18:00 | 02/05/21 | R 17 FC Juarez 2 Club Leon 1 |
| 18 | |  Atletico San Luis | 17 | 2 | 5 | 10 | 19 | 36 | -17 | 11 | B02:00 | 22/03/21 | R 12 Atletico San Luis 2 Club Santos Laguna 2 B01:00 | 27/03/21 | R 13 Club Necaxa 1 Atletico San Luis 1 M02:00 | 02/04/21 | R 14 Atletico San Luis 1 Atlas FC 2 M00:00 | 20/04/21 | R 15 Club Leon 3 Atletico San Luis 2 M01:00 | 27/04/21 | R 16 Atletico San Luis 1 Deportivo Toluca FC 2 M18:00 | 01/05/21 | R 17 CF Pachuca 4 Atletico San Luis 1 |
