| 1 | |  Ajax Amsterdam | 34 | 26 | 5 | 3 | 98 | 19 | 79 | 83 | B15:30 | 15/05/22 | R 34  Vitesse Arnhem 2 Ajax Amsterdam 2 G21:00 | 11/05/22 | R 33 Ajax Amsterdam 5 SC Heerenveen 0 B15:30 | 08/05/22 | R 32 AZ Alkmaar 2 Ajax Amsterdam 2 G19:45 | 30/04/22 | R 31 Ajax Amsterdam 3 PEC Zwolle 0 G17:30 | 23/04/22 | R 30 NEC Nijmegen 0 Ajax Amsterdam 1 G21:00 | 09/04/22 | R 29 Ajax Amsterdam 2 Sparta Rotterdam 1 |
| 2 | |  PSV Eindhoven | 34 | 26 | 3 | 5 | 86 | 42 | 44 | 81 | G15:30 | 15/05/22 | R 34 PEC Zwolle 1 PSV Eindhoven 2 G21:00 | 11/05/22 | R 33 PSV Eindhoven 3 NEC Nijmegen 2 B17:45 | 08/05/22 | R 32 Feyenoord Rotterdam 2 PSV Eindhoven 2 G15:30 | 01/05/22 | R 31 PSV Eindhoven 4 Willem II Tilburg 2 G22:00 | 23/04/22 | R 30 SC Cambuur 1 PSV Eindhoven 2 G15:30 | 10/04/22 | R 29 PSV Eindhoven 2 RKC Waalwijk 0 |
| 3 | |  Feyenoord Rotterdam | 34 | 22 | 5 | 7 | 76 | 34 | 42 | 71 | M15:30 | 15/05/22 | R 34 Feyenoord Rotterdam 1 FC Twente Enschede 2 G21:00 | 11/05/22 | R 33 Go Ahead Eagles 0 Feyenoord Rotterdam 1 B17:45 | 08/05/22 | R 32 Feyenoord Rotterdam 2 PSV Eindhoven 2 G17:45 | 01/05/22 | R 31 Fortuna Sittard 1 Feyenoord Rotterdam 3 G15:30 | 24/04/22 | R 30 Feyenoord Rotterdam 2 FC Utrecht 1 G17:45 | 10/04/22 | R 29 Heracles Almelo 1 Feyenoord Rotterdam 4 |
| 4 | |  FC Twente Enschede | 34 | 20 | 8 | 6 | 55 | 37 | 18 | 68 | G15:30 | 15/05/22 | R 34 Feyenoord Rotterdam 1 FC Twente Enschede 2 G21:00 | 11/05/22 | R 33 FC Twente Enschede 3 FC Groningen 0 M19:45 | 07/05/22 | R 32 FC Twente Enschede 1 Fortuna Sittard 2 B21:00 | 30/04/22 | R 31 Heracles Almelo 1 FC Twente Enschede 1 G21:00 | 22/04/22 | R 30 FC Twente Enschede 2 Sparta Rotterdam 0 G22:00 | 09/04/22 | R 29 NEC Nijmegen 0 FC Twente Enschede 2 |
| 5 | |  AZ Alkmaar | 34 | 18 | 7 | 9 | 64 | 44 | 20 | 61 | M15:30 | 15/05/22 | R 34 AZ Alkmaar 1 RKC Waalwijk 3 B21:00 | 11/05/22 | R 33 FC Utrecht 2 AZ Alkmaar 2 |
| 6 | |  Vitesse Arnhem | 34 | 15 | 6 | 13 | 42 | 51 | -9 | 51 | B15:30 | 15/05/22 | R 34 Vitesse Arnhem 2 Ajax Amsterdam 2 G21:00 | 11/05/22 | R 33 Fortuna Sittard 1 Vitesse Arnhem 2 |
| 7 | |  FC Utrecht | 34 | 12 | 11 | 11 | 51 | 46 | 5 | 47 | M15:30 | 15/05/22 | R 34 Willem II Tilburg 3 FC Utrecht 0 B21:00 | 11/05/22 | R 33 FC Utrecht 2 AZ Alkmaar 2 B21:00 | 07/05/22 | R 32 PEC Zwolle 1 FC Utrecht 1 G21:00 | 29/04/22 | R 31 FC Utrecht 1 NEC Nijmegen 0 |
| 8 | |  SC Heerenveen | 34 | 11 | 8 | 15 | 37 | 50 | -13 | 41 | G15:30 | 15/05/22 | R 34 SC Heerenveen 3 Go Ahead Eagles 1 M21:00 | 11/05/22 | R 33 Ajax Amsterdam 5 SC Heerenveen 0 G15:30 | 08/05/22 | R 32 Vitesse Arnhem 1 SC Heerenveen 2 B13:15 | 01/05/22 | R 31 SC Heerenveen 3 SC Cambuur 3 |
| 9 | |  SC Cambuur | 34 | 11 | 6 | 17 | 53 | 70 | -17 | 39 | G15:30 | 15/05/22 | R 34 FC Groningen 2 SC Cambuur 3 B21:00 | 11/05/22 | R 33 SC Cambuur 1 Willem II Tilburg 1 B21:00 | 06/05/22 | R 32 SC Cambuur 1 RKC Waalwijk 1 B13:15 | 01/05/22 | R 31 SC Heerenveen 3 SC Cambuur 3 M22:00 | 23/04/22 | R 30 SC Cambuur 1 PSV Eindhoven 2 M15:30 | 10/04/22 | R 29 Vitesse Arnhem 1 SC Cambuur 0 |
| 10 | |  RKC Waalwijk | 34 | 9 | 11 | 14 | 40 | 51 | -11 | 38 | G15:30 | 15/05/22 | R 34 AZ Alkmaar 1 RKC Waalwijk 3 G21:00 | 11/05/22 | R 33 RKC Waalwijk 2 Heracles Almelo 0 B21:00 | 06/05/22 | R 32 SC Cambuur 1 RKC Waalwijk 1 G21:00 | 01/05/22 | R 31 RKC Waalwijk 3 FC Groningen 1 M21:00 | 23/04/22 | R 30 RKC Waalwijk 0 PEC Zwolle 2 M15:30 | 10/04/22 | R 29 PSV Eindhoven 2 RKC Waalwijk 0 |
| 11 | |  NEC Nijmegen | 34 | 10 | 8 | 16 | 38 | 52 | -14 | 38 | M15:30 | 15/05/22 | R 34 NEC Nijmegen 0 Fortuna Sittard 1 M21:00 | 11/05/22 | R 33 PSV Eindhoven 3 NEC Nijmegen 2 G13:15 | 08/05/22 | R 32 NEC Nijmegen 1 Go Ahead Eagles 0 M21:00 | 29/04/22 | R 31 FC Utrecht 1 NEC Nijmegen 0 M17:30 | 23/04/22 | R 30 NEC Nijmegen 0 Ajax Amsterdam 1 M22:00 | 09/04/22 | R 29 NEC Nijmegen 0 FC Twente Enschede 2 |
| 12 | |  FC Groningen | 34 | 9 | 9 | 16 | 41 | 55 | -14 | 36 | M15:30 | 15/05/22 | R 34 FC Groningen 2 SC Cambuur 3 M21:00 | 11/05/22 | R 33 FC Twente Enschede 3 FC Groningen 0 M22:00 | 07/05/22 | R 32 FC Groningen 1 Sparta Rotterdam 2 M21:00 | 01/05/22 | R 31 RKC Waalwijk 3 FC Groningen 1 M15:30 | 24/04/22 | R 30 FC Groningen 0 Heracles Almelo 1 M13:15 | 10/04/22 | R 29 SC Heerenveen 3 FC Groningen 1 |
| 13 | |  Go Ahead Eagles | 34 | 10 | 6 | 18 | 37 | 51 | -14 | 36 | M15:30 | 15/05/22 | R 34 SC Heerenveen 3 Go Ahead Eagles 1 M21:00 | 11/05/22 | R 33 Go Ahead Eagles 0 Feyenoord Rotterdam 1 M13:15 | 08/05/22 | R 32 NEC Nijmegen 1 Go Ahead Eagles 0 M15:30 | 01/05/22 | R 31 Go Ahead Eagles 1 Vitesse Arnhem 2 M17:45 | 24/04/22 | R 30 Fortuna Sittard 1 Go Ahead Eagles 0 G21:00 | 08/04/22 | R 29 Go Ahead Eagles 4 Willem II Tilburg 0 |
| 14 | |  Sparta Rotterdam | 34 | 8 | 11 | 15 | 30 | 48 | -18 | 35 | G15:30 | 15/05/22 | R 34 Heracles Almelo 1 Sparta Rotterdam 3 G21:00 | 11/05/22 | R 33 Sparta Rotterdam 2 PEC Zwolle 0 G22:00 | 07/05/22 | R 32 FC Groningen 1 Sparta Rotterdam 2 B22:00 | 30/04/22 | R 31 Sparta Rotterdam 1 AZ Alkmaar 1 M21:00 | 22/04/22 | R 30 FC Twente Enschede 2 Sparta Rotterdam 0 M19:45 | 16/04/22 | R 23 Fortuna Sittard 3 Sparta Rotterdam 0 |
| 15 | |  Fortuna Sittard | 34 | 10 | 5 | 19 | 36 | 67 | -31 | 35 | G15:30 | 15/05/22 | R 34 NEC Nijmegen 0 Fortuna Sittard 1 M21:00 | 11/05/22 | R 33 Fortuna Sittard 1 Vitesse Arnhem 2 G19:45 | 07/05/22 | R 32 FC Twente Enschede 1 Fortuna Sittard 2 M17:45 | 01/05/22 | R 31 Fortuna Sittard 1 Feyenoord Rotterdam 3 G17:45 | 24/04/22 | R 30 Fortuna Sittard 1 Go Ahead Eagles 0 G19:45 | 16/04/22 | R 23 Fortuna Sittard 3 Sparta Rotterdam 0 |
| 16 | |  Heracles Almelo | 34 | 9 | 7 | 18 | 33 | 49 | -16 | 34 | M15:30 | 15/05/22 | R 34 Heracles Almelo 1 Sparta Rotterdam 3 M21:00 | 11/05/22 | R 33 RKC Waalwijk 2 Heracles Almelo 0 M21:00 | 07/05/22 | R 32 Willem II Tilburg 2 Heracles Almelo 0 B21:00 | 30/04/22 | R 31 Heracles Almelo 1 FC Twente Enschede 1 |
| 17 | |  Willem II Tilburg | 34 | 9 | 6 | 19 | 32 | 57 | -25 | 33 | G15:30 | 15/05/22 | R 34 Willem II Tilburg 3 FC Utrecht 0 B21:00 | 11/05/22 | R 33 SC Cambuur 1 Willem II Tilburg 1 G21:00 | 07/05/22 | R 32 Willem II Tilburg 2 Heracles Almelo 0 M15:30 | 01/05/22 | R 31 PSV Eindhoven 4 Willem II Tilburg 2 G13:15 | 24/04/22 | R 30 Willem II Tilburg 1 Vitesse Arnhem 0 M21:00 | 08/04/22 | R 29 Go Ahead Eagles 4 Willem II Tilburg 0 |
| 18 | |  PEC Zwolle | 34 | 7 | 6 | 21 | 26 | 52 | -26 | 27 | M15:30 | 15/05/22 | R 34 PEC Zwolle 1 PSV Eindhoven 2 M21:00 | 11/05/22 | R 33 Sparta Rotterdam 2 PEC Zwolle 0 B21:00 | 07/05/22 | R 32 PEC Zwolle 1 FC Utrecht 1 M19:45 | 30/04/22 | R 31 Ajax Amsterdam 3 PEC Zwolle 0 G21:00 | 23/04/22 | R 30 RKC Waalwijk 0 PEC Zwolle 2 G21:00 | 10/04/22 | R 29 PEC Zwolle 2 AZ Alkmaar 1 |
