| 1 | |  FC Emmen | 38 | 26 | 5 | 7 | 64 | 24 | 40 | 83 | B21:00 | 01/04/22 | R 33  De Graafschap 1 FC Emmen 1 G21:00 | 08/04/22 | R 34 FC Emmen 3 Jong AZ Alkmaar 0 G21:00 | 15/04/22 | R 35 Dordrecht 0 FC Emmen 1 G21:00 | 22/04/22 | R 36 FC Emmen 2 Roda JC Kerkrade 0 M21:00 | 29/04/22 | R 37 EVV Eindhoven 1 FC Emmen 0 G21:00 | 06/05/22 | R 38 FC Emmen 3 ADO Den Haag 0 |
| 2 | |  Volendam | 38 | 21 | 12 | 5 | 81 | 53 | 28 | 75 | B21:00 | 04/04/22 | R 32 Jong PSV Eindhoven 2 Volendam 2 G21:00 | 08/04/22 | R 34 Volendam 3 De Graafschap 1 G17:30 | 16/04/22 | R 35 Volendam 3 Jong Ajax Amsterdam 1 G21:00 | 22/04/22 | R 36 Den Bosch 1 Volendam 2 M21:00 | 29/04/22 | R 37 Dordrecht 3 Volendam 2 B21:00 | 06/05/22 | R 38 Volendam 2 EVV Eindhoven 2 |
| 3 | |  EVV Eindhoven | 38 | 21 | 8 | 9 | 69 | 43 | 26 | 71 | G21:00 | 01/04/22 | R 33 Dordrecht 0 EVV Eindhoven 1 G21:00 | 08/04/22 | R 34 EVV Eindhoven 3 Almere City FC 1 M21:00 | 15/04/22 | R 35 EVV Eindhoven 1 Jong PSV Eindhoven 3 G21:00 | 22/04/22 | R 36 Stormvogels Telstar 0 EVV Eindhoven 1 G21:00 | 29/04/22 | R 37 EVV Eindhoven 1 FC Emmen 0 B21:00 | 06/05/22 | R 38 Volendam 2 EVV Eindhoven 2 |
| 4 | |  ADO Den Haag | 38 | 22 | 7 | 9 | 76 | 53 | 23 | 67 | G21:00 | 01/04/22 | R 33 VVV Venlo 0 ADO Den Haag 5 G21:00 | 08/04/22 | R 34 ADO Den Haag 2 Helmond Sport 1 G21:00 | 15/04/22 | R 35 Jong AZ Alkmaar 0 ADO Den Haag 1 B13:15 | 24/04/22 | R 36 ADO Den Haag 1 Jong FC Utrecht 1 G21:00 | 29/04/22 | R 37 ADO Den Haag 1 Almere City FC 0 M21:00 | 06/05/22 | R 38 FC Emmen 3 ADO Den Haag 0 |
| 5 | |  Roda JC Kerkrade | 38 | 18 | 12 | 8 | 77 | 50 | 27 | 66 | G21:00 | 04/04/22 | R 32 Jong AZ Alkmaar 0 Roda JC Kerkrade 1 B21:00 | 08/04/22 | R 34 Roda JC Kerkrade 2 Jong Ajax Amsterdam 2 G21:00 | 15/04/22 | R 35 Roda JC Kerkrade 5 Helmond Sport 3 M21:00 | 22/04/22 | R 36 FC Emmen 2 Roda JC Kerkrade 0 M21:00 | 29/04/22 | R 37 Den Bosch 1 Roda JC Kerkrade 0 G21:00 | 06/05/22 | R 38 Roda JC Kerkrade 4 Stormvogels Telstar 3 |
| 6 | |  Excelsior Rotterdam | 38 | 19 | 9 | 10 | 82 | 57 | 25 | 66 | M21:00 | 01/04/22 | R 33 Almere City FC 3 Excelsior Rotterdam 0 M21:00 | 08/04/22 | R 34 Excelsior Rotterdam 1 Stormvogels Telstar 4 B21:00 | 15/04/22 | R 35 Maastricht 1 Excelsior Rotterdam 1 B21:00 | 22/04/22 | R 36 Excelsior Rotterdam 3 Jong AZ Alkmaar 3 B21:00 | 29/04/22 | R 37 VVV Venlo 2 Excelsior Rotterdam 2 B21:00 | 06/05/22 | R 38 Excelsior Rotterdam 2 NAC Breda 2 |
| 7 | |  Jong Ajax Amsterdam | 38 | 18 | 9 | 11 | 82 | 63 | 19 | 63 | G21:00 | 04/04/22 | R 32 Jong Ajax Amsterdam 4 TOP Oss 1 B21:00 | 08/04/22 | R 34 Roda JC Kerkrade 2 Jong Ajax Amsterdam 2 M17:30 | 16/04/22 | R 35 Volendam 3 Jong Ajax Amsterdam 1 G21:00 | 25/04/22 | R 36 Jong Ajax Amsterdam 6 VVV Venlo 1 M21:00 | 29/04/22 | R 37 Maastricht 1 Jong Ajax Amsterdam 0 B21:00 | 06/05/22 | R 38 Jong Ajax Amsterdam 1 De Graafschap 1 |
| 8 | |  NAC Breda | 38 | 16 | 11 | 11 | 60 | 45 | 15 | 59 | M21:00 | 04/04/22 | R 32 Jong FC Utrecht 1 NAC Breda 0 G21:00 | 08/04/22 | R 34 NAC Breda 3 VVV Venlo 1 G22:00 | 16/04/22 | R 35 Almere City FC 1 NAC Breda 2 M21:00 | 22/04/22 | R 36 NAC Breda 1 Dordrecht 2 G21:00 | 29/04/22 | R 37 NAC Breda 3 TOP Oss 0 B21:00 | 06/05/22 | R 38 Excelsior Rotterdam 2 NAC Breda 2 |
| 9 | |  De Graafschap | 38 | 15 | 11 | 12 | 52 | 43 | 9 | 56 | B21:00 | 01/04/22 | R 33 De Graafschap 1 FC Emmen 1 M21:00 | 08/04/22 | R 34 Volendam 3 De Graafschap 1 M21:00 | 15/04/22 | R 35 De Graafschap 1 TOP Oss 2 G21:00 | 22/04/22 | R 36 Helmond Sport 0 De Graafschap 4 B21:00 | 29/04/22 | R 37 De Graafschap 1 Jong PSV Eindhoven 1 B21:00 | 06/05/22 | R 38 Jong Ajax Amsterdam 1 De Graafschap 1 |
| 10 | |  VVV Venlo | 38 | 14 | 6 | 18 | 50 | 64 | -14 | 48 | M21:00 | 01/04/22 | R 33 VVV Venlo 0 ADO Den Haag 5 M21:00 | 08/04/22 | R 34 NAC Breda 3 VVV Venlo 1 G21:00 | 15/04/22 | R 35 VVV Venlo 3 Stormvogels Telstar 2 M21:00 | 25/04/22 | R 36 Jong Ajax Amsterdam 6 VVV Venlo 1 B21:00 | 29/04/22 | R 37 VVV Venlo 2 Excelsior Rotterdam 2 G21:00 | 06/05/22 | R 38 Jong FC Utrecht 2 VVV Venlo 3 |
| 11 | |  Den Bosch | 38 | 14 | 5 | 19 | 42 | 61 | -19 | 47 | G21:00 | 01/04/22 | R 33 Stormvogels Telstar 1 Den Bosch 2 G21:00 | 08/04/22 | R 34 Den Bosch 3 Dordrecht 0 G21:00 | 18/04/22 | R 35 Jong FC Utrecht 0 Den Bosch 1 M21:00 | 22/04/22 | R 36 Den Bosch 1 Volendam 2 G21:00 | 29/04/22 | R 37 Den Bosch 1 Roda JC Kerkrade 0 B21:00 | 06/05/22 | R 38 Helmond Sport 1 Den Bosch 1 |
| 12 | |  Jong PSV Eindhoven | 38 | 11 | 11 | 16 | 61 | 63 | -2 | 44 | B21:00 | 04/04/22 | R 32 Jong PSV Eindhoven 2 Volendam 2 M21:00 | 08/04/22 | R 34 TOP Oss 2 Jong PSV Eindhoven 0 G21:00 | 15/04/22 | R 35 EVV Eindhoven 1 Jong PSV Eindhoven 3 B21:00 | 25/04/22 | R 36 Jong PSV Eindhoven 2 Maastricht 2 B21:00 | 29/04/22 | R 37 De Graafschap 1 Jong PSV Eindhoven 1 B21:00 | 06/05/22 | R 38 Jong PSV Eindhoven 1 Dordrecht 1 |
| 13 | |  Jong AZ Alkmaar | 38 | 12 | 6 | 20 | 39 | 50 | -11 | 42 | M21:00 | 04/04/22 | R 32 Jong AZ Alkmaar 0 Roda JC Kerkrade 1 M21:00 | 08/04/22 | R 34 FC Emmen 3 Jong AZ Alkmaar 0 M21:00 | 15/04/22 | R 35 Jong AZ Alkmaar 0 ADO Den Haag 1 B21:00 | 22/04/22 | R 36 Excelsior Rotterdam 3 Jong AZ Alkmaar 3 M21:00 | 29/04/22 | R 37 Jong AZ Alkmaar 0 Helmond Sport 1 G21:00 | 06/05/22 | R 38 Almere City FC 0 Jong AZ Alkmaar 3 |
| 14 | |  Almere City FC | 38 | 11 | 8 | 19 | 57 | 69 | -12 | 41 | G21:00 | 01/04/22 | R 33 Almere City FC 3 Excelsior Rotterdam 0 M21:00 | 08/04/22 | R 34 EVV Eindhoven 3 Almere City FC 1 M22:00 | 16/04/22 | R 35 Almere City FC 1 NAC Breda 2 G21:00 | 22/04/22 | R 36 TOP Oss 2 Almere City FC 3 M21:00 | 29/04/22 | R 37 ADO Den Haag 1 Almere City FC 0 M21:00 | 06/05/22 | R 38 Almere City FC 0 Jong AZ Alkmaar 3 |
| 15 | |  TOP Oss | 38 | 11 | 8 | 19 | 48 | 62 | -14 | 41 | M21:00 | 04/04/22 | R 32 Jong Ajax Amsterdam 4 TOP Oss 1 G21:00 | 08/04/22 | R 34 TOP Oss 2 Jong PSV Eindhoven 0 G21:00 | 15/04/22 | R 35 De Graafschap 1 TOP Oss 2 M21:00 | 22/04/22 | R 36 TOP Oss 2 Almere City FC 3 M21:00 | 29/04/22 | R 37 NAC Breda 3 TOP Oss 0 M21:00 | 06/05/22 | R 38 TOP Oss 0 Maastricht 1 |
| 16 | |  Maastricht | 38 | 12 | 4 | 22 | 43 | 75 | -32 | 40 | G21:00 | 01/04/22 | R 33 Helmond Sport 1 Maastricht 2 M21:00 | 08/04/22 | R 34 Maastricht 2 Jong FC Utrecht 4 B21:00 | 15/04/22 | R 35 Maastricht 1 Excelsior Rotterdam 1 B21:00 | 25/04/22 | R 36 Jong PSV Eindhoven 2 Maastricht 2 G21:00 | 29/04/22 | R 37 Maastricht 1 Jong Ajax Amsterdam 0 G21:00 | 06/05/22 | R 38 TOP Oss 0 Maastricht 1 |
| 17 | |  Dordrecht | 38 | 10 | 9 | 19 | 53 | 77 | -24 | 39 | M21:00 | 01/04/22 | R 33 Dordrecht 0 EVV Eindhoven 1 M21:00 | 08/04/22 | R 34 Den Bosch 3 Dordrecht 0 M21:00 | 15/04/22 | R 35 Dordrecht 0 FC Emmen 1 G21:00 | 22/04/22 | R 36 NAC Breda 1 Dordrecht 2 G21:00 | 29/04/22 | R 37 Dordrecht 3 Volendam 2 B21:00 | 06/05/22 | R 38 Jong PSV Eindhoven 1 Dordrecht 1 |
| 18 | |  Jong FC Utrecht | 38 | 11 | 5 | 22 | 43 | 67 | -24 | 38 | G21:00 | 04/04/22 | R 32 Jong FC Utrecht 1 NAC Breda 0 G21:00 | 08/04/22 | R 34 Maastricht 2 Jong FC Utrecht 4 M21:00 | 18/04/22 | R 35 Jong FC Utrecht 0 Den Bosch 1 B13:15 | 24/04/22 | R 36 ADO Den Haag 1 Jong FC Utrecht 1 G21:00 | 29/04/22 | R 37 Stormvogels Telstar 1 Jong FC Utrecht 3 M21:00 | 06/05/22 | R 38 Jong FC Utrecht 2 VVV Venlo 3 |
| 19 | |  Stormvogels Telstar | 38 | 8 | 11 | 19 | 47 | 74 | -27 | 35 | M21:00 | 01/04/22 | R 33 Stormvogels Telstar 1 Den Bosch 2 G21:00 | 08/04/22 | R 34 Excelsior Rotterdam 1 Stormvogels Telstar 4 M21:00 | 15/04/22 | R 35 VVV Venlo 3 Stormvogels Telstar 2 M21:00 | 22/04/22 | R 36 Stormvogels Telstar 0 EVV Eindhoven 1 M21:00 | 29/04/22 | R 37 Stormvogels Telstar 1 Jong FC Utrecht 3 M21:00 | 06/05/22 | R 38 Roda JC Kerkrade 4 Stormvogels Telstar 3 |
| 20 | |  Helmond Sport | 38 | 8 | 7 | 23 | 39 | 72 | -33 | 28 | M21:00 | 01/04/22 | R 33 Helmond Sport 1 Maastricht 2 M21:00 | 08/04/22 | R 34 ADO Den Haag 2 Helmond Sport 1 M21:00 | 15/04/22 | R 35 Roda JC Kerkrade 5 Helmond Sport 3 M21:00 | 22/04/22 | R 36 Helmond Sport 0 De Graafschap 4 G21:00 | 29/04/22 | R 37 Jong AZ Alkmaar 0 Helmond Sport 1 B21:00 | 06/05/22 | R 38 Helmond Sport 1 Den Bosch 1 |
