| 1 | |  Independiente Petrolero | 30 | 20 | 5 | 5 | 59 | 33 | 26 | 65 | G22:00 | 12/12/21 | R 30  Guabira Montero 2 Independiente Petrolero 3 G22:00 | 05/12/21 | R 29 Independiente Petrolero 2 CA Nacional Potosi 0 G22:00 | 02/12/21 | R 28 Real Potosi 0 Independiente Petrolero 5 G02:30 | 28/11/21 | R 27 Independiente Petrolero 2 Real Santa Cruz 1 M02:30 | 21/11/21 | R 26 Royal Pari FC 3 Independiente Petrolero 1 G01:15 | 02/11/21 | R 25 Independiente Petrolero 4 San Jose Oruro 0 |
| 2 | |  Always Ready | 30 | 19 | 7 | 4 | 66 | 31 | 35 | 64 | G22:00 | 12/12/21 | R 30 Club Aurora 3 Always Ready 4 B22:00 | 05/12/21 | R 29 Always Ready 1 Club Bolivar 1 G03:00 | 01/12/21 | R 28 Blooming 1 Always Ready 2 G22:00 | 27/11/21 | R 27 Always Ready 6 Guabira Montero 1 M22:00 | 21/11/21 | R 26 Real Potosi 3 Always Ready 2 G22:00 | 31/10/21 | R 25 Always Ready 2 Royal Pari FC 1 |
| 3 | |  The Strongest | 30 | 19 | 6 | 5 | 57 | 24 | 33 | 63 | M22:00 | 12/12/21 | R 30 Real Santa Cruz 1 The Strongest 0 G22:00 | 05/12/21 | R 29 The Strongest 2 San Jose Oruro 0 B03:00 | 03/12/21 | R 28 CD Real Tomayapo 0 The Strongest 0 G01:15 | 27/11/21 | R 27 The Strongest 3 Club Aurora 0 G00:15 | 22/11/21 | R 26 Club Bolivar 0 The Strongest 1 G22:00 | 30/10/21 | R 25 The Strongest 2 Blooming 1 |
| 4 | |  Club Bolivar | 30 | 16 | 8 | 6 | 63 | 29 | 34 | 56 | G02:00 | 11/12/21 | R 30 Club Bolivar 2 Royal Pari FC 0 B22:00 | 05/12/21 | R 29 Always Ready 1 Club Bolivar 1 G02:30 | 02/12/21 | R 28 Club Bolivar 3 CA Palmaflor 1 M00:15 | 29/11/21 | R 27 Jorge Wilstermann 1 Club Bolivar 0 M00:15 | 22/11/21 | R 26 Club Bolivar 0 The Strongest 1 G02:30 | 01/11/21 | R 25 Oriente Petrolero 1 Club Bolivar 3 |
| 5 | |  Royal Pari FC | 30 | 16 | 3 | 11 | 66 | 45 | 21 | 51 | M02:00 | 11/12/21 | R 30 Club Bolivar 2 Royal Pari FC 0 G22:00 | 05/12/21 | R 29 Royal Pari FC 4 Blooming 3 M22:00 | 02/12/21 | R 28 Guabira Montero 3 Royal Pari FC 2 G22:00 | 28/11/21 | R 27 Royal Pari FC 5 Real Potosi 0 G02:30 | 21/11/21 | R 26 Royal Pari FC 3 Independiente Petrolero 1 M22:00 | 31/10/21 | R 25 Always Ready 2 Royal Pari FC 1 |
| 6 | |  Oriente Petrolero | 30 | 15 | 6 | 9 | 46 | 29 | 17 | 51 | M22:00 | 10/12/21 | R 30 CA Nacional Potosi 1 Oriente Petrolero 0 G03:30 | 05/12/21 | R 29 Oriente Petrolero 2 Real Santa Cruz 0 G22:45 | 30/11/21 | R 28 San Jose Oruro 0 Oriente Petrolero 2 G03:30 | 27/11/21 | R 27 Oriente Petrolero 3 CD Real Tomayapo 1 G00:15 | 21/11/21 | R 26 Club Aurora 1 Oriente Petrolero 2 M02:30 | 01/11/21 | R 25 Oriente Petrolero 1 Club Bolivar 3 |
| 7 | |  Jorge Wilstermann | 29 | 14 | 4 | 11 | 61 | 48 | 13 | 46 | G02:00 | 07/12/21 | R 29 Jorge Wilstermann 3 CD Real Tomayapo 0 B02:00 | 02/12/21 | R 28 Club Aurora 1 Jorge Wilstermann 1 G00:15 | 29/11/21 | R 27 Jorge Wilstermann 1 Club Bolivar 0 B02:30 | 22/11/21 | R 26 Blooming 2 Jorge Wilstermann 2 G00:15 | 31/10/21 | R 25 Jorge Wilstermann 2 Guabira Montero 1 B01:15 | 27/10/21 | R 24 Real Potosi 2 Jorge Wilstermann 2 |
| 8 | |  Guabira Montero | 30 | 13 | 5 | 12 | 47 | 47 | 0 | 44 | M22:00 | 12/12/21 | R 30 Guabira Montero 2 Independiente Petrolero 3 G22:00 | 05/12/21 | R 29 Real Potosi 1 Guabira Montero 3 G22:00 | 02/12/21 | R 28 Guabira Montero 3 Royal Pari FC 2 M22:00 | 27/11/21 | R 27 Always Ready 6 Guabira Montero 1 G22:00 | 20/11/21 | R 26 Guabira Montero 2 CA Palmaflor 0 M00:15 | 31/10/21 | R 25 Jorge Wilstermann 2 Guabira Montero 1 |
| 9 | |  CA Palmaflor | 30 | 11 | 7 | 12 | 42 | 45 | -3 | 40 | B22:00 | 11/12/21 | R 30 CD Real Tomayapo 3 CA Palmaflor 3 G22:00 | 04/12/21 | R 29 CA Palmaflor 3 Club Aurora 2 M02:30 | 02/12/21 | R 28 Club Bolivar 3 CA Palmaflor 1 G00:15 | 28/11/21 | R 27 CA Palmaflor 3 Blooming 0 M22:00 | 20/11/21 | R 26 Guabira Montero 2 CA Palmaflor 0 M03:30 | 02/11/21 | R 25 CA Palmaflor 0 Real Potosi 1 |
| 10 | |  CA Nacional Potosi | 30 | 10 | 9 | 11 | 45 | 46 | -1 | 39 | G22:00 | 10/12/21 | R 30 CA Nacional Potosi 1 Oriente Petrolero 0 M22:00 | 05/12/21 | R 29 Independiente Petrolero 2 CA Nacional Potosi 0 B22:00 | 01/12/21 | R 28 Real Santa Cruz 1 CA Nacional Potosi 1 G22:00 | 26/11/21 | R 27 CA Nacional Potosi 7 San Jose Oruro 1 M03:00 | 23/11/21 | R 26 CD Real Tomayapo 3 CA Nacional Potosi 0 B00:15 | 01/11/21 | R 25 CA Nacional Potosi 0 Club Aurora 0 |
| 11 | |  Real Santa Cruz | 30 | 11 | 5 | 14 | 39 | 47 | -8 | 38 | G22:00 | 12/12/21 | R 30 Real Santa Cruz 1 The Strongest 0 M03:30 | 05/12/21 | R 29 Oriente Petrolero 2 Real Santa Cruz 0 B22:00 | 01/12/21 | R 28 Real Santa Cruz 1 CA Nacional Potosi 1 M02:30 | 28/11/21 | R 27 Independiente Petrolero 2 Real Santa Cruz 1 G22:45 | 22/11/21 | R 26 San Jose Oruro 1 Real Santa Cruz 2 M22:00 | 07/11/21 | R 24 Club Aurora 4 Real Santa Cruz 1 |
| 12 | |  Club Aurora | 30 | 9 | 6 | 15 | 40 | 51 | -11 | 33 | M22:00 | 12/12/21 | R 30 Club Aurora 3 Always Ready 4 M22:00 | 04/12/21 | R 29 CA Palmaflor 3 Club Aurora 2 B02:00 | 02/12/21 | R 28 Club Aurora 1 Jorge Wilstermann 1 M01:15 | 27/11/21 | R 27 The Strongest 3 Club Aurora 0 M00:15 | 21/11/21 | R 26 Club Aurora 1 Oriente Petrolero 2 G22:00 | 07/11/21 | R 24 Club Aurora 4 Real Santa Cruz 1 |
| 13 | |  CD Real Tomayapo | 30 | 9 | 5 | 16 | 28 | 45 | -17 | 32 | B22:00 | 11/12/21 | R 30 CD Real Tomayapo 3 CA Palmaflor 3 M02:00 | 07/12/21 | R 29 Jorge Wilstermann 3 CD Real Tomayapo 0 B03:00 | 03/12/21 | R 28 CD Real Tomayapo 0 The Strongest 0 M03:30 | 27/11/21 | R 27 Oriente Petrolero 3 CD Real Tomayapo 1 G03:00 | 23/11/21 | R 26 CD Real Tomayapo 3 CA Nacional Potosi 0 M22:00 | 01/11/21 | R 25 Real Santa Cruz 2 CD Real Tomayapo 0 |
| 14 | |  Blooming | 30 | 7 | 5 | 18 | 34 | 56 | -22 | 26 | G02:00 | 12/12/21 | R 30 Blooming 1 Real Potosi 0 M22:00 | 05/12/21 | R 29 Royal Pari FC 4 Blooming 3 M03:00 | 01/12/21 | R 28 Blooming 1 Always Ready 2 M00:15 | 28/11/21 | R 27 CA Palmaflor 3 Blooming 0 B02:30 | 22/11/21 | R 26 Blooming 2 Jorge Wilstermann 2 M22:00 | 30/10/21 | R 25 The Strongest 2 Blooming 1 |
| 15 | |  Real Potosi | 30 | 7 | 4 | 19 | 30 | 63 | -33 | 25 | M02:00 | 12/12/21 | R 30 Blooming 1 Real Potosi 0 M22:00 | 05/12/21 | R 29 Real Potosi 1 Guabira Montero 3 M22:00 | 02/12/21 | R 28 Real Potosi 0 Independiente Petrolero 5 M22:00 | 28/11/21 | R 27 Royal Pari FC 5 Real Potosi 0 |
| 16 | |  San Jose Oruro | 29 | 0 | 1 | 28 | 9 | 93 | -84 | -11 | M22:00 | 05/12/21 | R 29 The Strongest 2 San Jose Oruro 0 M22:45 | 30/11/21 | R 28 San Jose Oruro 0 Oriente Petrolero 2 M22:00 | 26/11/21 | R 27 CA Nacional Potosi 7 San Jose Oruro 1 M22:45 | 22/11/21 | R 26 San Jose Oruro 1 Real Santa Cruz 2 M01:15 | 02/11/21 | R 25 Independiente Petrolero 4 San Jose Oruro 0 M01:15 | 28/10/21 | R 24 CD Real Tomayapo 1 San Jose Oruro 0 |
