| 1 | |  Gral Caballero | 34 | 22 | 7 | 5 | 67 | 31 | 36 | 73 | G23:00 | 22/10/21 | R 34  CA 3 de Febrero CDE 1 Gral Caballero 4 G15:30 | 16/10/21 | R 33 Gral Caballero 2 Fulgencio Yegros 0 M15:30 | 08/10/21 | R 32 Gral Caballero 0 Deportivo Capiata 1 G15:30 | 03/10/21 | R 31 Sportivo Iteno 2 Gral Caballero 4 G21:45 | 27/09/21 | R 30 Gral Caballero 4 Rubio Nu 1 B22:00 | 20/09/21 | R 29 Deportivo Santani 0 Gral Caballero 0 |
| 2 | |  Resistencia FC | 34 | 16 | 13 | 5 | 44 | 22 | 22 | 61 | B21:30 | 26/10/21 | R 34 Resistencia FC 0 Independiente Campo Grande 0 G15:30 | 17/10/21 | R 33 Deportivo Capiata 0 Resistencia FC 4 G15:30 | 09/10/21 | R 32 Club Fernando 0 Resistencia FC 1 G00:00 | 02/10/21 | R 31 Resistencia FC 2 CS 2 de Mayo 1 M16:00 | 24/09/21 | R 30 Sportivo Trinidense 1 Resistencia FC 0 G17:00 | 19/09/21 | R 29 Resistencia FC 2 Atyra FC 1 |
| 3 | |  Tacuary Asuncion | 34 | 16 | 9 | 9 | 54 | 44 | 10 | 57 | G21:30 | 26/10/21 | R 34 Tacuary Asuncion 4 Rubio Nu 0 B15:30 | 17/10/21 | R 33 Deportivo Santani 1 Tacuary Asuncion 1 G15:30 | 09/10/21 | R 32 Tacuary Asuncion 3 Club Guarani de Trinidad 2 B01:00 | 05/10/21 | R 31 Sportivo San Lorenzo 2 Tacuary Asuncion 2 G17:00 | 27/09/21 | R 30 Tacuary Asuncion 1 General Diaz Luque 0 G21:45 | 17/09/21 | R 29 Independiente Campo Grande 0 Tacuary Asuncion 2 |
| 4 | |  Sportivo Ameliano | 34 | 16 | 8 | 10 | 51 | 37 | 14 | 56 | G21:30 | 26/10/21 | R 34 Sportivo Ameliano 3 Sportivo Iteno 0 G15:30 | 17/10/21 | R 33 Rubio Nu 0 Sportivo Ameliano 1 G15:30 | 08/10/21 | R 32 Sportivo Ameliano 2 Deportivo Santani 0 B21:45 | 01/10/21 | R 31 Club Guarani de Trinidad 0 Sportivo Ameliano 0 G17:00 | 25/09/21 | R 30 Sportivo Ameliano 3 Sportivo San Lorenzo 0 G17:00 | 18/09/21 | R 29 General Diaz Luque 0 Sportivo Ameliano 2 |
| 5 | |  Sportivo San Lorenzo | 34 | 14 | 11 | 9 | 60 | 44 | 16 | 53 | G21:30 | 26/10/21 | R 34 CS 2 de Mayo 1 Sportivo San Lorenzo 8 G15:30 | 18/10/21 | R 33 Sportivo San Lorenzo 5 Sportivo Trinidense 1 G20:45 | 11/10/21 | R 32 Atyra FC 1 Sportivo San Lorenzo 2 B01:00 | 05/10/21 | R 31 Sportivo San Lorenzo 2 Tacuary Asuncion 2 M17:00 | 25/09/21 | R 30 Sportivo Ameliano 3 Sportivo San Lorenzo 0 M01:00 | 21/09/21 | R 29 Sportivo San Lorenzo 0 CA 3 de Febrero CDE 1 |
| 6 | |  Sportivo Trinidense | 34 | 14 | 10 | 10 | 48 | 48 | 0 | 52 | G21:30 | 21/10/21 | R 34 Sportivo Trinidense 2 Club Guarani de Trinidad 1 M15:30 | 18/10/21 | R 33 Sportivo San Lorenzo 5 Sportivo Trinidense 1 G20:45 | 11/10/21 | R 32 Sportivo Trinidense 3 General Diaz Luque 1 B16:30 | 02/10/21 | R 31 Independiente Campo Grande 0 Sportivo Trinidense 0 G16:00 | 24/09/21 | R 30 Sportivo Trinidense 1 Resistencia FC 0 B17:00 | 17/09/21 | R 29 Club Fernando 2 Sportivo Trinidense 2 |
| 7 | |  Independiente Campo Grande | 34 | 14 | 9 | 11 | 38 | 30 | 8 | 51 | B21:30 | 26/10/21 | R 34 Resistencia FC 0 Independiente Campo Grande 0 G01:00 | 16/10/21 | R 33 Independiente Campo Grande 2 Club Fernando 1 G15:30 | 09/10/21 | R 32 CS 2 de Mayo 0 Independiente Campo Grande 2 B16:30 | 02/10/21 | R 31 Independiente Campo Grande 0 Sportivo Trinidense 0 M17:00 | 25/09/21 | R 30 Atyra FC 2 Independiente Campo Grande 1 M21:45 | 17/09/21 | R 29 Independiente Campo Grande 0 Tacuary Asuncion 2 |
| 8 | |  CA 3 de Febrero CDE | 34 | 11 | 15 | 8 | 48 | 44 | 4 | 48 | M23:00 | 22/10/21 | R 34 CA 3 de Febrero CDE 1 Gral Caballero 4 B15:30 | 17/10/21 | R 33 Sportivo Iteno 0 CA 3 de Febrero CDE 0 G15:30 | 09/10/21 | R 32 CA 3 de Febrero CDE 2 Rubio Nu 1 M16:00 | 03/10/21 | R 31 Deportivo Santani 2 CA 3 de Febrero CDE 0 B02:00 | 25/09/21 | R 30 CA 3 de Febrero CDE 1 Club Guarani de Trinidad 1 G01:00 | 21/09/21 | R 29 Sportivo San Lorenzo 0 CA 3 de Febrero CDE 1 |
| 9 | |  Club Fernando | 34 | 10 | 15 | 9 | 40 | 36 | 4 | 45 | G22:00 | 20/10/21 | R 34 Club Fernando 2 General Diaz Luque 0 M01:00 | 16/10/21 | R 33 Independiente Campo Grande 2 Club Fernando 1 M15:30 | 09/10/21 | R 32 Club Fernando 0 Resistencia FC 1 M16:30 | 02/10/21 | R 31 Deportivo Capiata 1 Club Fernando 0 B21:45 | 26/09/21 | R 30 CS 2 de Mayo 0 Club Fernando 0 B17:00 | 17/09/21 | R 29 Club Fernando 2 Sportivo Trinidense 2 |
| 10 | |  Atyra FC | 34 | 10 | 13 | 11 | 47 | 45 | 2 | 43 | M15:30 | 25/10/21 | R 34 Atyra FC 0 Deportivo Santani 2 M15:30 | 17/10/21 | R 33 Club Guarani de Trinidad 1 Atyra FC 0 M20:45 | 11/10/21 | R 32 Atyra FC 1 Sportivo San Lorenzo 2 M16:30 | 01/10/21 | R 31 General Diaz Luque 3 Atyra FC 1 G17:00 | 25/09/21 | R 30 Atyra FC 2 Independiente Campo Grande 1 M17:00 | 19/09/21 | R 29 Resistencia FC 2 Atyra FC 1 |
| 11 | |  Deportivo Santani | 33 | 9 | 13 | 11 | 38 | 42 | -4 | 40 | G15:30 | 25/10/21 | R 34 Atyra FC 0 Deportivo Santani 2 B15:30 | 17/10/21 | R 33 Deportivo Santani 1 Tacuary Asuncion 1 M15:30 | 08/10/21 | R 32 Sportivo Ameliano 2 Deportivo Santani 0 G16:00 | 03/10/21 | R 31 Deportivo Santani 2 CA 3 de Febrero CDE 0 M17:00 | 26/09/21 | R 30 Fulgencio Yegros 2 Deportivo Santani 1 B22:00 | 20/09/21 | R 29 Deportivo Santani 0 Gral Caballero 0 |
| 12 | |  Club Guarani de Trinidad | 32 | 10 | 9 | 13 | 34 | 37 | -3 | 39 | M21:30 | 21/10/21 | R 34 Sportivo Trinidense 2 Club Guarani de Trinidad 1 G15:30 | 17/10/21 | R 33 Club Guarani de Trinidad 1 Atyra FC 0 M15:30 | 09/10/21 | R 32 Tacuary Asuncion 3 Club Guarani de Trinidad 2 B21:45 | 01/10/21 | R 31 Club Guarani de Trinidad 0 Sportivo Ameliano 0 B02:00 | 25/09/21 | R 30 CA 3 de Febrero CDE 1 Club Guarani de Trinidad 1 G22:00 | 19/09/21 | R 29 Club Guarani de Trinidad 1 Fulgencio Yegros 0 |
| 13 | |  Deportivo Capiata | 34 | 8 | 15 | 11 | 34 | 47 | -13 | 39 | G15:30 | 25/10/21 | R 34 Fulgencio Yegros 1 Deportivo Capiata 2 M15:30 | 17/10/21 | R 33 Deportivo Capiata 0 Resistencia FC 4 G15:30 | 08/10/21 | R 32 Gral Caballero 0 Deportivo Capiata 1 G16:30 | 02/10/21 | R 31 Deportivo Capiata 1 Club Fernando 0 M17:00 | 26/09/21 | R 30 Sportivo Iteno 3 Deportivo Capiata 0 B17:00 | 19/09/21 | R 29 Deportivo Capiata 0 CS 2 de Mayo 0 |
| 14 | |  Sportivo Iteno | 34 | 8 | 15 | 11 | 26 | 39 | -13 | 39 | M21:30 | 26/10/21 | R 34 Sportivo Ameliano 3 Sportivo Iteno 0 B15:30 | 17/10/21 | R 33 Sportivo Iteno 0 CA 3 de Febrero CDE 0 G15:30 | 08/10/21 | R 32 Fulgencio Yegros 0 Sportivo Iteno 1 M15:30 | 03/10/21 | R 31 Sportivo Iteno 2 Gral Caballero 4 G17:00 | 26/09/21 | R 30 Sportivo Iteno 3 Deportivo Capiata 0 B17:00 | 18/09/21 | R 29 Rubio Nu 0 Sportivo Iteno 0 |
| 15 | |  Rubio Nu | 33 | 9 | 11 | 13 | 34 | 44 | -10 | 38 | M21:30 | 26/10/21 | R 34 Tacuary Asuncion 4 Rubio Nu 0 M15:30 | 17/10/21 | R 33 Rubio Nu 0 Sportivo Ameliano 1 M15:30 | 09/10/21 | R 32 CA 3 de Febrero CDE 2 Rubio Nu 1 G22:00 | 04/10/21 | R 31 Rubio Nu 2 Fulgencio Yegros 1 M21:45 | 27/09/21 | R 30 Gral Caballero 4 Rubio Nu 1 B17:00 | 18/09/21 | R 29 Rubio Nu 0 Sportivo Iteno 0 |
| 16 | |  CS 2 de Mayo | 34 | 9 | 9 | 16 | 39 | 55 | -16 | 36 | M21:30 | 26/10/21 | R 34 CS 2 de Mayo 1 Sportivo San Lorenzo 8 M20:45 | 15/10/21 | R 33 General Diaz Luque 3 CS 2 de Mayo 1 M15:30 | 09/10/21 | R 32 CS 2 de Mayo 0 Independiente Campo Grande 2 M00:00 | 02/10/21 | R 31 Resistencia FC 2 CS 2 de Mayo 1 B21:45 | 26/09/21 | R 30 CS 2 de Mayo 0 Club Fernando 0 B17:00 | 19/09/21 | R 29 Deportivo Capiata 0 CS 2 de Mayo 0 |
| 17 | |  General Diaz Luque | 34 | 6 | 6 | 22 | 25 | 53 | -28 | 24 | M22:00 | 20/10/21 | R 34 Club Fernando 2 General Diaz Luque 0 G20:45 | 15/10/21 | R 33 General Diaz Luque 3 CS 2 de Mayo 1 M20:45 | 11/10/21 | R 32 Sportivo Trinidense 3 General Diaz Luque 1 G16:30 | 01/10/21 | R 31 General Diaz Luque 3 Atyra FC 1 M17:00 | 27/09/21 | R 30 Tacuary Asuncion 1 General Diaz Luque 0 M17:00 | 18/09/21 | R 29 General Diaz Luque 0 Sportivo Ameliano 2 |
| 18 | |  Fulgencio Yegros | 34 | 5 | 6 | 23 | 25 | 54 | -29 | 21 | M15:30 | 25/10/21 | R 34 Fulgencio Yegros 1 Deportivo Capiata 2 M15:30 | 16/10/21 | R 33 Gral Caballero 2 Fulgencio Yegros 0 M15:30 | 08/10/21 | R 32 Fulgencio Yegros 0 Sportivo Iteno 1 M22:00 | 04/10/21 | R 31 Rubio Nu 2 Fulgencio Yegros 1 G17:00 | 26/09/21 | R 30 Fulgencio Yegros 2 Deportivo Santani 1 M22:00 | 19/09/21 | R 29 Club Guarani de Trinidad 1 Fulgencio Yegros 0 |
