| 1 | |  AS Roma | 34 | 21 | 8 | 5 | 64 | 33 | 31 | 71 | G15:00 | 15/05/22 | R 34  AS Roma 4 ACF Fiorentina 1 G18:00 | 07/05/22 | R 33 US Lecce 2 AS Roma 3 G11:45 | 01/05/22 | R 32 AS Roma 2 Cagliari Calcio 1 B12:00 | 24/04/22 | R 31 Genoa CFC 1 AS Roma 1 |
| 2 | |  Inter Milano | 34 | 18 | 10 | 6 | 60 | 33 | 27 | 64 | B15:00 | 15/05/22 | R 34 UC Sampdoria 0 Inter Milano 0 B18:00 | 09/05/22 | R 33 Inter Milano 2 AC Milan 2 G18:00 | 29/04/22 | R 32 Inter Milano 3 Spal 1 G14:00 | 23/04/22 | R 31 Torino FC 0 Inter Milano 2 |
| 3 | |  Cagliari Calcio | 34 | 18 | 7 | 9 | 59 | 44 | 15 | 61 | M15:00 | 15/05/22 | R 34 Empoli FC 1 Cagliari Calcio 0 G16:30 | 11/05/22 | R 31 Cagliari Calcio 2 Juventus Turin 0 G14:00 | 07/05/22 | R 33 Cagliari Calcio 4 Pescara Calcio 3 M11:45 | 01/05/22 | R 32 AS Roma 2 Cagliari Calcio 1 |
| 4 | |  Atalanta BC | 34 | 17 | 7 | 10 | 62 | 49 | 13 | 58 | M15:00 | 15/05/22 | R 34 Atalanta BC 2 Sassuolo Calcio 4 M17:00 | 09/05/22 | R 33 Torino FC 2 Atalanta BC 0 B18:00 | 30/04/22 | R 32 Atalanta BC 2 Hellas Verona FC 2 G14:00 | 24/04/22 | R 31 Spal 2 Atalanta BC 3 G17:00 | 20/04/22 | R 30 Atalanta BC 1 Genoa CFC 0 |
| 5 | |  Juventus Turin | 34 | 17 | 6 | 11 | 68 | 48 | 20 | 57 | G15:00 | 15/05/22 | R 34 Juventus Turin 5 Spal 2 M16:30 | 11/05/22 | R 31 Cagliari Calcio 2 Juventus Turin 0 B14:00 | 07/05/22 | R 33 Sassuolo Calcio 2 Juventus Turin 2 G16:00 | 04/05/22 | R 30 Juventus Turin 3 Empoli FC 0 |
| 6 | |  UC Sampdoria | 34 | 15 | 8 | 11 | 63 | 52 | 11 | 53 | B15:00 | 15/05/22 | R 34 UC Sampdoria 0 Inter Milano 0 G15:00 | 09/05/22 | R 33 ACF Fiorentina 1 UC Sampdoria 2 G12:00 | 30/04/22 | R 32 UC Sampdoria 1 US Lecce 0 B14:00 | 25/04/22 | R 31 Hellas Verona FC 4 UC Sampdoria 4 B15:00 | 20/04/22 | R 30 UC Sampdoria 3 Sassuolo Calcio 3 |
| 7 | |  ACF Fiorentina | 34 | 15 | 6 | 13 | 48 | 50 | -2 | 51 | M15:00 | 15/05/22 | R 34 AS Roma 4 ACF Fiorentina 1 M15:00 | 09/05/22 | R 33 ACF Fiorentina 1 UC Sampdoria 2 M13:00 | 30/04/22 | R 32 Bologna FC 1 ACF Fiorentina 0 M12:00 | 23/04/22 | R 31 SSC Napoli 3 ACF Fiorentina 2 G15:00 | 20/04/22 | R 30 ACF Fiorentina 3 Spal 2 G15:30 | 16/04/22 | R 29 Torino FC 0 ACF Fiorentina 1 |
| 8 | |  Sassuolo Calcio | 34 | 13 | 9 | 12 | 50 | 36 | 14 | 48 | G15:00 | 15/05/22 | R 34 Atalanta BC 2 Sassuolo Calcio 4 B14:00 | 07/05/22 | R 33 Sassuolo Calcio 2 Juventus Turin 2 M16:00 | 30/04/22 | R 32 Pescara Calcio 1 Sassuolo Calcio 0 G18:00 | 25/04/22 | R 31 Sassuolo Calcio 3 Empoli FC 0 B15:00 | 20/04/22 | R 30 UC Sampdoria 3 Sassuolo Calcio 3 M18:00 | 16/04/22 | R 29 Sassuolo Calcio 1 Hellas Verona FC 2 |
| 9 | |  Hellas Verona FC | 34 | 13 | 7 | 14 | 53 | 54 | -1 | 46 | G13:00 | 15/05/22 | R 34 SSC Napoli 1 Hellas Verona FC 2 G12:00 | 07/05/22 | R 33 Hellas Verona FC 6 Bologna FC 0 B18:00 | 30/04/22 | R 32 Atalanta BC 2 Hellas Verona FC 2 B14:00 | 25/04/22 | R 31 Hellas Verona FC 4 UC Sampdoria 4 B12:00 | 21/04/22 | R 30 Hellas Verona FC 2 Cagliari Calcio 2 G18:00 | 16/04/22 | R 29 Sassuolo Calcio 1 Hellas Verona FC 2 |
| 10 | |  Empoli FC | 34 | 12 | 10 | 12 | 42 | 44 | -2 | 46 | G15:00 | 15/05/22 | R 34 Empoli FC 1 Cagliari Calcio 0 B12:00 | 08/05/22 | R 33 Genoa CFC 1 Empoli FC 1 M16:00 | 04/05/22 | R 30 Juventus Turin 3 Empoli FC 0 G16:00 | 29/04/22 | R 32 Empoli FC 3 AC Milan 1 M18:00 | 25/04/22 | R 31 Sassuolo Calcio 3 Empoli FC 0 G16:00 | 16/04/22 | R 29 Empoli FC 2 Bologna FC 1 |
| 11 | |  Bologna FC | 34 | 14 | 4 | 16 | 46 | 53 | -7 | 46 | B16:00 | 14/05/22 | R 34 Pescara Calcio 1 Bologna FC 1 M12:00 | 07/05/22 | R 33 Hellas Verona FC 6 Bologna FC 0 G13:00 | 30/04/22 | R 32 Bologna FC 1 ACF Fiorentina 0 G16:00 | 23/04/22 | R 31 AC Milan 1 Bologna FC 4 G17:00 | 19/04/22 | R 30 Bologna FC 1 Torino FC 0 M16:00 | 16/04/22 | R 29 Empoli FC 2 Bologna FC 1 |
| 12 | |  Torino FC | 34 | 11 | 10 | 13 | 42 | 46 | -4 | 43 | M13:00 | 15/05/22 | R 34 US Lecce 2 Torino FC 1 G17:00 | 09/05/22 | R 33 Torino FC 2 Atalanta BC 0 M20:00 | 29/04/22 | R 32 Juventus Turin 4 Torino FC 1 M14:00 | 23/04/22 | R 31 Torino FC 0 Inter Milano 2 M17:00 | 19/04/22 | R 30 Bologna FC 1 Torino FC 0 M15:30 | 16/04/22 | R 29 Torino FC 0 ACF Fiorentina 1 |
| 13 | |  AC Milan | 34 | 13 | 4 | 17 | 55 | 63 | -8 | 43 | G13:00 | 15/05/22 | R 34 AC Milan 4 Genoa CFC 2 B18:00 | 09/05/22 | R 33 Inter Milano 2 AC Milan 2 M16:00 | 29/04/22 | R 32 Empoli FC 3 AC Milan 1 M16:00 | 23/04/22 | R 31 AC Milan 1 Bologna FC 4 M13:00 | 20/04/22 | R 30 Pescara Calcio 3 AC Milan 1 M17:30 | 16/04/22 | R 29 AC Milan 1 UC Sampdoria 4 |
| 14 | |  US Lecce | 34 | 10 | 10 | 14 | 42 | 48 | -6 | 40 | G13:00 | 15/05/22 | R 34 US Lecce 2 Torino FC 1 M18:00 | 07/05/22 | R 33 US Lecce 2 AS Roma 3 M12:00 | 30/04/22 | R 32 UC Sampdoria 1 US Lecce 0 G16:00 | 24/04/22 | R 31 US Lecce 5 Pescara Calcio 1 M15:00 | 19/04/22 | R 30 Inter Milano 1 US Lecce 0 B11:30 | 16/04/22 | R 29 US Lecce 1 Juventus Turin 1 |
| 15 | |  SSC Napoli | 34 | 11 | 7 | 16 | 43 | 57 | -14 | 40 | M13:00 | 15/05/22 | R 34 SSC Napoli 1 Hellas Verona FC 2 M12:00 | 07/05/22 | R 33 Spal 4 SSC Napoli 3 B14:00 | 30/04/22 | R 32 SSC Napoli 1 Genoa CFC 1 G12:00 | 23/04/22 | R 31 SSC Napoli 3 ACF Fiorentina 2 |
| 16 | |  Genoa CFC | 34 | 9 | 11 | 14 | 39 | 42 | -3 | 38 | M13:00 | 15/05/22 | R 34 AC Milan 4 Genoa CFC 2 B12:00 | 08/05/22 | R 33 Genoa CFC 1 Empoli FC 1 B14:00 | 30/04/22 | R 32 SSC Napoli 1 Genoa CFC 1 B12:00 | 24/04/22 | R 31 Genoa CFC 1 AS Roma 1 |
| 17 | |  Spal | 34 | 6 | 8 | 20 | 40 | 80 | -40 | 26 | M15:00 | 15/05/22 | R 34 Juventus Turin 5 Spal 2 G12:00 | 07/05/22 | R 33 Spal 4 SSC Napoli 3 M18:00 | 29/04/22 | R 32 Inter Milano 3 Spal 1 M14:00 | 24/04/22 | R 31 Spal 2 Atalanta BC 3 M15:00 | 20/04/22 | R 30 ACF Fiorentina 3 Spal 2 M16:00 | 16/04/22 | R 29 Spal 0 AS Roma 1 |
| 18 | |  Pescara Calcio | 34 | 5 | 4 | 25 | 35 | 79 | -44 | 19 | B16:00 | 14/05/22 | R 34 Pescara Calcio 1 Bologna FC 1 M14:00 | 07/05/22 | R 33 Cagliari Calcio 4 Pescara Calcio 3 G16:00 | 30/04/22 | R 32 Pescara Calcio 1 Sassuolo Calcio 0 M16:00 | 24/04/22 | R 31 US Lecce 5 Pescara Calcio 1 G13:00 | 20/04/22 | R 30 Pescara Calcio 3 AC Milan 1 M13:30 | 16/04/22 | R 29 Pescara Calcio 2 Atalanta BC 3 |
