| 1 | |  FK Zeleziarne Podbrezova | 30 | 24 | 2 | 4 | 86 | 25 | 61 | 74 | M18:00 | 15/04/22 | R 25  FK Zeleziarne Podbrezova 2 FC Petrzalka 3 G17:30 | 23/04/22 | R 26 FK Slavoj Trebisov 0 FK Zeleziarne Podbrezova 4 G18:00 | 29/04/22 | R 27 FK Zeleziarne Podbrezova 8 FK Dubnica Nad Vahom 0 G14:00 | 07/05/22 | R 28 MSK Zilina B 3 FK Zeleziarne Podbrezova 5 G18:00 | 13/05/22 | R 29 FK Zeleziarne Podbrezova 7 Partizan Bardejov 1 G18:00 | 20/05/22 | R 30 Slovan Bratislava B 1 FK Zeleziarne Podbrezova 2 |
| 2 | |  MFK Dukla Banska Bystrica | 30 | 21 | 6 | 3 | 62 | 24 | 38 | 69 | G18:00 | 20/04/22 | R 23 MFK Dukla Banska Bystrica 3 FC Petrzalka 1 G11:30 | 24/04/22 | R 26 MSK Zilina B 0 MFK Dukla Banska Bystrica 1 G17:00 | 30/04/22 | R 27 MFK Dukla Banska Bystrica 3 Partizan Bardejov 1 B17:00 | 06/05/22 | R 28 Slovan Bratislava B 2 MFK Dukla Banska Bystrica 2 G18:00 | 13/05/22 | R 29 MFK Dukla Banska Bystrica 3 FK Humenne 0 G18:00 | 20/05/22 | R 30 FC Rohoznik 1 MFK Dukla Banska Bystrica 3 |
| 3 | |  MFK Skalica | 30 | 19 | 5 | 6 | 49 | 20 | 29 | 62 | G19:00 | 16/04/22 | R 25 MFK Skalica 4 FK Slavoj Trebisov 1 M17:30 | 23/04/22 | R 26 FK Dubnica Nad Vahom 3 MFK Skalica 1 G19:00 | 30/04/22 | R 27 MFK Skalica 4 MSK Zilina B 0 G18:00 | 07/05/22 | R 28 Partizan Bardejov 0 MFK Skalica 3 G18:00 | 13/05/22 | R 29 MFK Skalica 3 Slovan Bratislava B 0 M18:00 | 20/05/22 | R 30 FK Humenne 2 MFK Skalica 1 |
| 4 | |  KFC Komarno | 30 | 17 | 8 | 5 | 51 | 29 | 22 | 59 | G18:00 | 15/04/22 | R 25 FK Kosice 0 KFC Komarno 1 M17:30 | 23/04/22 | R 26 KFC Komarno 0 FC Stk 1914 Samorin 2 G17:30 | 29/04/22 | R 27 MSK Puchov 0 KFC Komarno 1 G18:00 | 07/05/22 | R 28 KFC Komarno 4 MSK Namestovo 1 G18:00 | 13/05/22 | R 29 KFC Komarno 6 FC Petrzalka 0 G18:00 | 20/05/22 | R 30 FK Slavoj Trebisov 0 KFC Komarno 2 |
| 5 | |  FK Kosice | 30 | 17 | 5 | 8 | 73 | 38 | 35 | 56 | M18:00 | 15/04/22 | R 25 FK Kosice 0 KFC Komarno 1 G11:30 | 24/04/22 | R 26 FC Petrzalka 3 FK Kosice 8 G19:00 | 29/04/22 | R 27 FK Kosice 4 FK Slavoj Trebisov 1 G19:00 | 07/05/22 | R 28 FK Kosice 2 FK Dubnica Nad Vahom 0 G18:00 | 13/05/22 | R 29 FK Kosice 2 MSK Zilina B 1 B18:00 | 20/05/22 | R 30 FK Kosice 2 Partizan Bardejov 2 |
| 6 | |  FK Humenne | 30 | 16 | 8 | 6 | 36 | 30 | 6 | 56 | G17:00 | 16/04/22 | R 25 FK Humenne 2 Partizan Bardejov 1 G11:30 | 23/04/22 | R 26 Slovan Bratislava B 2 FK Humenne 3 G17:30 | 30/04/22 | R 27 MSK Namestovo 0 FK Humenne 2 G18:00 | 07/05/22 | R 28 FK Humenne 4 FC Rohoznik 2 M18:00 | 13/05/22 | R 29 MFK Dukla Banska Bystrica 3 FK Humenne 0 G18:00 | 20/05/22 | R 30 FK Humenne 2 MFK Skalica 1 |
| 7 | |  FC Stk 1914 Samorin | 30 | 13 | 5 | 12 | 47 | 42 | 5 | 44 | M11:30 | 17/04/22 | R 25 FC Stk 1914 Samorin 2 MSK Puchov 3 G17:30 | 23/04/22 | R 26 KFC Komarno 0 FC Stk 1914 Samorin 2 G11:30 | 01/05/22 | R 27 FC Stk 1914 Samorin 2 FC Petrzalka 0 M18:00 | 07/05/22 | R 28 FK Slavoj Trebisov 4 FC Stk 1914 Samorin 0 G18:00 | 13/05/22 | R 29 FC Stk 1914 Samorin 4 FK Dubnica Nad Vahom 0 B18:00 | 20/05/22 | R 30 MSK Zilina B 1 FC Stk 1914 Samorin 1 |
| 8 | |  FC Petrzalka | 30 | 12 | 5 | 13 | 54 | 48 | 6 | 41 | M18:00 | 20/04/22 | R 23 MFK Dukla Banska Bystrica 3 FC Petrzalka 1 M11:30 | 24/04/22 | R 26 FC Petrzalka 3 FK Kosice 8 M11:30 | 01/05/22 | R 27 FC Stk 1914 Samorin 2 FC Petrzalka 0 G11:30 | 08/05/22 | R 28 FC Petrzalka 3 MSK Puchov 1 M18:00 | 13/05/22 | R 29 KFC Komarno 6 FC Petrzalka 0 G18:00 | 20/05/22 | R 30 FC Petrzalka 6 MSK Namestovo 0 |
| 9 | |  MSK Zilina B | 30 | 10 | 7 | 13 | 46 | 48 | -2 | 37 | B12:00 | 17/04/22 | R 25 FC Rohoznik 1 MSK Zilina B 1 M11:30 | 24/04/22 | R 26 MSK Zilina B 0 MFK Dukla Banska Bystrica 1 M19:00 | 30/04/22 | R 27 MFK Skalica 4 MSK Zilina B 0 M14:00 | 07/05/22 | R 28 MSK Zilina B 3 FK Zeleziarne Podbrezova 5 M18:00 | 13/05/22 | R 29 FK Kosice 2 MSK Zilina B 1 B18:00 | 20/05/22 | R 30 MSK Zilina B 1 FC Stk 1914 Samorin 1 |
| 10 | |  FK Slavoj Trebisov | 30 | 9 | 7 | 14 | 28 | 48 | -20 | 34 | M19:00 | 16/04/22 | R 25 MFK Skalica 4 FK Slavoj Trebisov 1 M17:30 | 23/04/22 | R 26 FK Slavoj Trebisov 0 FK Zeleziarne Podbrezova 4 M19:00 | 29/04/22 | R 27 FK Kosice 4 FK Slavoj Trebisov 1 G18:00 | 07/05/22 | R 28 FK Slavoj Trebisov 4 FC Stk 1914 Samorin 0 M18:00 | 13/05/22 | R 29 MSK Puchov 2 FK Slavoj Trebisov 0 M18:00 | 20/05/22 | R 30 FK Slavoj Trebisov 0 KFC Komarno 2 |
| 11 | |  FK Dubnica Nad Vahom | 30 | 8 | 7 | 15 | 33 | 51 | -18 | 31 | M17:30 | 16/04/22 | R 25 MFK Dukla Banska Bystrica 1 FK Dubnica Nad Vahom 0 G17:30 | 23/04/22 | R 26 FK Dubnica Nad Vahom 3 MFK Skalica 1 M18:00 | 29/04/22 | R 27 FK Zeleziarne Podbrezova 8 FK Dubnica Nad Vahom 0 M19:00 | 07/05/22 | R 28 FK Kosice 2 FK Dubnica Nad Vahom 0 M18:00 | 13/05/22 | R 29 FC Stk 1914 Samorin 4 FK Dubnica Nad Vahom 0 B18:00 | 20/05/22 | R 30 FK Dubnica Nad Vahom 0 MSK Puchov 0 |
| 12 | |  MSK Puchov | 30 | 8 | 5 | 17 | 36 | 49 | -13 | 29 | G11:30 | 17/04/22 | R 25 FC Stk 1914 Samorin 2 MSK Puchov 3 G17:30 | 23/04/22 | R 26 MSK Puchov 2 MSK Namestovo 0 M17:30 | 29/04/22 | R 27 MSK Puchov 0 KFC Komarno 1 M11:30 | 08/05/22 | R 28 FC Petrzalka 3 MSK Puchov 1 G18:00 | 13/05/22 | R 29 MSK Puchov 2 FK Slavoj Trebisov 0 B18:00 | 20/05/22 | R 30 FK Dubnica Nad Vahom 0 MSK Puchov 0 |
| 13 | |  FC Rohoznik | 30 | 8 | 5 | 17 | 30 | 58 | -28 | 29 | B12:00 | 17/04/22 | R 25 FC Rohoznik 1 MSK Zilina B 1 G17:30 | 23/04/22 | R 26 Partizan Bardejov 2 FC Rohoznik 3 M17:00 | 30/04/22 | R 27 FC Rohoznik 0 Slovan Bratislava B 6 M18:00 | 07/05/22 | R 28 FK Humenne 4 FC Rohoznik 2 G18:00 | 13/05/22 | R 29 MSK Namestovo 0 FC Rohoznik 1 M18:00 | 20/05/22 | R 30 FC Rohoznik 1 MFK Dukla Banska Bystrica 3 |
| 14 | |  Slovan Bratislava B | 30 | 7 | 5 | 18 | 36 | 61 | -25 | 26 | M17:30 | 16/04/22 | R 25 MSK Namestovo 2 Slovan Bratislava B 1 M11:30 | 23/04/22 | R 26 Slovan Bratislava B 2 FK Humenne 3 G17:00 | 30/04/22 | R 27 FC Rohoznik 0 Slovan Bratislava B 6 B17:00 | 06/05/22 | R 28 Slovan Bratislava B 2 MFK Dukla Banska Bystrica 2 M18:00 | 13/05/22 | R 29 MFK Skalica 3 Slovan Bratislava B 0 M18:00 | 20/05/22 | R 30 Slovan Bratislava B 1 FK Zeleziarne Podbrezova 2 |
| 15 | |  Partizan Bardejov | 30 | 3 | 9 | 18 | 26 | 54 | -28 | 18 | M17:00 | 16/04/22 | R 25 FK Humenne 2 Partizan Bardejov 1 M17:30 | 23/04/22 | R 26 Partizan Bardejov 2 FC Rohoznik 3 M17:00 | 30/04/22 | R 27 MFK Dukla Banska Bystrica 3 Partizan Bardejov 1 M18:00 | 07/05/22 | R 28 Partizan Bardejov 0 MFK Skalica 3 M18:00 | 13/05/22 | R 29 FK Zeleziarne Podbrezova 7 Partizan Bardejov 1 B18:00 | 20/05/22 | R 30 FK Kosice 2 Partizan Bardejov 2 |
| 16 | |  MSK Namestovo | 30 | 2 | 3 | 25 | 19 | 87 | -68 | 9 | G17:30 | 16/04/22 | R 25 MSK Namestovo 2 Slovan Bratislava B 1 M17:30 | 23/04/22 | R 26 MSK Puchov 2 MSK Namestovo 0 M17:30 | 30/04/22 | R 27 MSK Namestovo 0 FK Humenne 2 M18:00 | 07/05/22 | R 28 KFC Komarno 4 MSK Namestovo 1 M18:00 | 13/05/22 | R 29 MSK Namestovo 0 FC Rohoznik 1 M18:00 | 20/05/22 | R 30 FC Petrzalka 6 MSK Namestovo 0 |
