| 1 | |  FK Shkendija | 33 | 22 | 9 | 2 | 69 | 26 | 43 | 75 | B17:00 | 16/05/21 | R 33  FK Shkendija 1 FK Shkupi 1 G17:00 | 09/05/21 | R 32 FK Makedonija Gjorge Petrov 3 FK Shkendija 4 M14:00 | 01/05/21 | R 31 FK Shkendija 0 FC Struga Trim Lum 2 G14:00 | 28/04/21 | R 30 Rabotnicki 3 FK Shkendija 5 G14:00 | 25/04/21 | R 29 FK Shkendija 3 FK Borec Veles 1 G14:00 | 18/04/21 | R 28 FK Belasica Strumica 0 FK Shkendija 3 |
| 2 | |  FK Shkupi | 33 | 16 | 11 | 6 | 41 | 24 | 17 | 59 | B17:00 | 16/05/21 | R 33 FK Shkendija 1 FK Shkupi 1 B17:00 | 09/05/21 | R 32 FK Shkupi 0 Pelister Bitola 0 B14:00 | 01/05/21 | R 31 FK Shkupi 0 FK Makedonija Gjorge Petrov 0 B14:00 | 28/04/21 | R 30 FC Struga Trim Lum 0 FK Shkupi 0 G14:00 | 25/04/21 | R 29 FK Shkupi 2 Rabotnicki 0 G14:00 | 18/04/21 | R 28 FK Borec Veles 0 FK Shkupi 1 |
| 3 | |  FC Struga Trim Lum | 33 | 15 | 12 | 6 | 39 | 24 | 15 | 57 | G17:00 | 16/05/21 | R 33 FK Sileks Kratovo 0 FC Struga Trim Lum 1 G17:00 | 09/05/21 | R 32 FC Struga Trim Lum 1 FK Vardar Üsküp 0 G14:00 | 01/05/21 | R 31 FK Shkendija 0 FC Struga Trim Lum 2 B14:00 | 28/04/21 | R 30 FC Struga Trim Lum 0 FK Shkupi 0 G14:00 | 25/04/21 | R 29 FK Makedonija Gjorge Petrov 2 FC Struga Trim Lum 3 G14:00 | 18/04/21 | R 28 FC Struga Trim Lum 3 Pelister Bitola 0 |
| 4 | |  FK Makedonija Gjorge Petrov | 33 | 16 | 7 | 10 | 53 | 43 | 10 | 55 | G17:00 | 16/05/21 | R 33 FK Vardar Üsküp 0 FK Makedonija Gjorge Petrov 2 M17:00 | 09/05/21 | R 32 FK Makedonija Gjorge Petrov 3 FK Shkendija 4 B14:00 | 01/05/21 | R 31 FK Shkupi 0 FK Makedonija Gjorge Petrov 0 G14:00 | 28/04/21 | R 30 FK Makedonija Gjorge Petrov 3 Pelister Bitola 0 M14:00 | 25/04/21 | R 29 FK Makedonija Gjorge Petrov 2 FC Struga Trim Lum 3 B14:00 | 18/04/21 | R 28 Rabotnicki 2 FK Makedonija Gjorge Petrov 2 |
| 5 | |  Rabotnicki | 33 | 11 | 15 | 7 | 45 | 39 | 6 | 48 | B17:00 | 16/05/21 | R 33 Renova Dzepciste 1 Rabotnicki 1 G17:00 | 09/05/21 | R 32 Rabotnicki 3 FK Sileks Kratovo 1 G14:00 | 01/05/21 | R 31 FK Vardar Üsküp 1 Rabotnicki 3 M14:00 | 28/04/21 | R 30 Rabotnicki 3 FK Shkendija 5 M14:00 | 25/04/21 | R 29 FK Shkupi 2 Rabotnicki 0 B14:00 | 18/04/21 | R 28 Rabotnicki 2 FK Makedonija Gjorge Petrov 2 |
| 6 | |  Pelister Bitola | 33 | 12 | 9 | 12 | 34 | 38 | -4 | 45 | G17:00 | 16/05/21 | R 33 Pelister Bitola 2 FK Belasica Strumica 0 B17:00 | 09/05/21 | R 32 FK Shkupi 0 Pelister Bitola 0 G14:00 | 01/05/21 | R 31 Pelister Bitola 3 FK Akademija Pandev Brera Strumica 1 M14:00 | 28/04/21 | R 30 FK Makedonija Gjorge Petrov 3 Pelister Bitola 0 G14:00 | 25/04/21 | R 29 Pelister Bitola 1 Renova Dzepciste 0 M14:00 | 18/04/21 | R 28 FC Struga Trim Lum 3 Pelister Bitola 0 |
| 7 | |  FK Akademija Pandev Brera Strumica | 33 | 12 | 5 | 16 | 32 | 36 | -4 | 41 | G17:00 | 16/05/21 | R 33 FK Akademija Pandev Brera Strumica 3 FK Borec Veles 1 G17:00 | 09/05/21 | R 32 FK Belasica Strumica 0 FK Akademija Pandev Brera Strumica 2 M14:00 | 01/05/21 | R 31 Pelister Bitola 3 FK Akademija Pandev Brera Strumica 1 B14:00 | 28/04/21 | R 30 FK Akademija Pandev Brera Strumica 1 Renova Dzepciste 1 M14:00 | 24/04/21 | R 29 FK Sileks Kratovo 3 FK Akademija Pandev Brera Strumica 2 G14:00 | 18/04/21 | R 28 FK Akademija Pandev Brera Strumica 3 FK Vardar Üsküp 0 |
| 8 | |  FK Borec Veles | 33 | 11 | 7 | 15 | 32 | 36 | -4 | 40 | M17:00 | 16/05/21 | R 33 FK Akademija Pandev Brera Strumica 3 FK Borec Veles 1 G17:00 | 09/05/21 | R 32 FK Borec Veles 2 Renova Dzepciste 0 B14:00 | 01/05/21 | R 31 FK Sileks Kratovo 1 FK Borec Veles 1 G14:00 | 28/04/21 | R 30 FK Borec Veles 2 FK Vardar Üsküp 0 M14:00 | 25/04/21 | R 29 FK Shkendija 3 FK Borec Veles 1 M14:00 | 18/04/21 | R 28 FK Borec Veles 0 FK Shkupi 1 |
| 9 | |  FK Sileks Kratovo | 33 | 10 | 6 | 17 | 49 | 45 | 4 | 36 | M17:00 | 16/05/21 | R 33 FK Sileks Kratovo 0 FC Struga Trim Lum 1 M17:00 | 09/05/21 | R 32 Rabotnicki 3 FK Sileks Kratovo 1 B14:00 | 01/05/21 | R 31 FK Sileks Kratovo 1 FK Borec Veles 1 G14:00 | 28/04/21 | R 30 FK Belasica Strumica 1 FK Sileks Kratovo 3 G14:00 | 24/04/21 | R 29 FK Sileks Kratovo 3 FK Akademija Pandev Brera Strumica 2 |
| 10 | |  Renova Dzepciste | 33 | 8 | 12 | 13 | 36 | 46 | -10 | 36 | B17:00 | 16/05/21 | R 33 Renova Dzepciste 1 Rabotnicki 1 M17:00 | 09/05/21 | R 32 FK Borec Veles 2 Renova Dzepciste 0 G14:00 | 01/05/21 | R 31 Renova Dzepciste 3 FK Belasica Strumica 1 B14:00 | 28/04/21 | R 30 FK Akademija Pandev Brera Strumica 1 Renova Dzepciste 1 M14:00 | 25/04/21 | R 29 Pelister Bitola 1 Renova Dzepciste 0 |
| 11 | |  FK Vardar Üsküp | 33 | 7 | 10 | 16 | 32 | 60 | -28 | 31 | M17:00 | 16/05/21 | R 33 FK Vardar Üsküp 0 FK Makedonija Gjorge Petrov 2 M17:00 | 09/05/21 | R 32 FC Struga Trim Lum 1 FK Vardar Üsküp 0 M14:00 | 01/05/21 | R 31 FK Vardar Üsküp 1 Rabotnicki 3 M14:00 | 28/04/21 | R 30 FK Borec Veles 2 FK Vardar Üsküp 0 G14:00 | 25/04/21 | R 29 FK Vardar Üsküp 1 FK Belasica Strumica 0 M14:00 | 18/04/21 | R 28 FK Akademija Pandev Brera Strumica 3 FK Vardar Üsküp 0 |
| 12 | |  FK Belasica Strumica | 33 | 4 | 5 | 24 | 23 | 68 | -45 | 17 | M17:00 | 16/05/21 | R 33 Pelister Bitola 2 FK Belasica Strumica 0 M17:00 | 09/05/21 | R 32 FK Belasica Strumica 0 FK Akademija Pandev Brera Strumica 2 M14:00 | 01/05/21 | R 31 Renova Dzepciste 3 FK Belasica Strumica 1 M14:00 | 28/04/21 | R 30 FK Belasica Strumica 1 FK Sileks Kratovo 3 M14:00 | 25/04/21 | R 29 FK Vardar Üsküp 1 FK Belasica Strumica 0 M14:00 | 18/04/21 | R 28 FK Belasica Strumica 0 FK Shkendija 3 |
