The match will kick off at 2000GMT at Schalke's Arena AufSchalke - Gelsenkirchen Stadium.
The sides drew 0-0 in the first match in Istanbul on Oct. 24.
So far, Galatasaray have played 274 matches in UEFA competitions, winning 99 games and losing 103.
To date, the UEFA Champions League Cup has proved elusive for Turkish clubs, with the 'Lions' being the only Turkish club to have won the UEFA Cup in 1999-2000 and the 2000 UEFA Super Cup.
Galatasaray's other rivals in Group D are Portugal's Porto and Russia's Lokomotiv Moscow.
Porto are at the top of the group with 7 points followed by Schalke with 5 points, Galatasaray with 4 points and Lokomotiv Moscow with no point
