In a statement, Fenerbahce Beko said that Berkay Candan, Lorenzo Brown, Kenan Sipahi, Kyle O'Quinn, Alex Perez and Johnny Hamilton left the Istanbul club.
It thanked the athletes for their service and wished them good luck in their careers.
Earlier this week, Fenerbahce Beko's Lithuanian forward Edgaras Ulanovas also left the club on a mutual termination.
In the 2020-21 season, Fenerbahce Beko failed in Turkey's ING Basketball Super Lig, losing this year's title to Anadolu Efes 3-0.
Fenerbahce Beko were also eliminated in the 2021 Turkish Airlines EuroLeague playoffs.
CSKA Moscow won the series 3-0 to knock Fenerbahce Beko out of the tournament in April.